Kanamycin Pharmacology

Kanamycin

About Kanamycin
N/A
Mechanism of Action of Kanamycin
Kanamycin exerts its bactericidal action against gram- negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1. Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2. Misleading of m-RNA codon by bacterial ribosome, 3. Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4. Bacterial cell lysis.
Pharmacokinets of Kanamycin
Absorption: Poorly absorbed orally, but well absorbed intra muscularly.
Distribution: Distributed Extracellularly.
Metabolism: Not metabolized.
Excretion: Excreted through urine.
Onset of Action for Kanamycin
1 hour
Duration of Action for Kanamycin
N/A
Half Life of Kanamycin
2 to 3 hours
Side Effects of Kanamycin
1. Ototoxicity mainly cochlear damage and hearing loss
2. Allergic manifestations
3. Nephrotoxicity
4. Dizziness Seizures
5. Nausea Vomiting
Contra-indications of Kanamycin
1. Hypersensitive to the drug or other amino glycosides
2. Along with other nephrotoxic drugs
3. Renal impairment
4. Auditory disorders
Special Precautions while taking Kanamycin
1.Renal impairment
2.Neuromuscular disorders
3.Myasthenia gravis
4.Parkinsonism

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use cautiously
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Kanamycin
1. Tuberculosis
2. Urinary tract infections
3. Gastrointestinal problems

Interactions for Kanamycin
Amphotericin B, Cisplatin, Cephalosporin, Vancomycin, Methoxyflurane, Frusemide, Bumetanide: Increased nephrotoxicity.
Anaesthetics, Neuromuscular blocking agents (Tubocurarine): Risk of neuromuscular blockade and respiratory paralysis.
Penicillin, Cephalosporins, Carbenicillin, Ticarcillin: Exert antibiotic synergism, especially useful in Pseudomonas infections.
Loop diuretics: Concurrent use of these agents may increase the risk of respiratory paralysis and renal dysfunction.
Lab Tests: Aminoglycoside serum levels: Guard against in vitro inactivation of aminoglycosides by ?-lactum antibiotics in patients on combination therapy.
Typical Dosage for Kanamycin
0.5 to 1 gm intramuscularly twice daily or thrice daily
Schedule of Kanamycin
H
Storage Requirements for Kanamycin
Store at room temperature.
Effects of Missed Dosage of Kanamycin
Take the missed dose as soon as remember and If it is the time for next dose then skip the missed dose and take the regular dose.
Effects of Overdose of Kanamycin
An overdose results in Ototoxicity, nephrotoxicity, neuromuscular disorders, & hypersensitivity manifestations. Treatment includes removal of drug by dialysis, & drug treatment with neostigmine, Ca, & Prednisolone.

Home Delivery for Kanamycin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including kanamycin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for kanamycin and other medicines and health products. Home delivery services for kanamycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take kanamycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for kanamycin before they complete the sale. You can get this information while placing the order for kanamycin with the pharmacy.

Kanamycin is a generic medicine name and there are several brands available for it. Some of the brands for kanamycin might be better known than kanamycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have kanamycin in stock, you can ask for one of the branded alternatives for kanamycin.