Netilmicin Pharmacology

Netilmicin

About Netilmicin

A semisynthetic Aminoglycosides, Protein Synthesis Inhibitor, Antibiotic.

Mechanism of Action of Netilmicin

Netilmicin exerts its bactericidal action against gram- negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1. Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2. Misleading of m-RNA codon by bacterial ribosome, 3. Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4. Bacterial cell lysis. Some bacterial strains resistant to other amino glycosides are sensitive to Netilmicin & it is less toxic than other amino glycosides

Pharmacokinets of Netilmicin

Absorption: Poorly absorbed orally, Distribution: Distributed extracellularly. CSF penetration & intraocular penetration poor. Metabolism: Not metabolized, Excretion: Excreted mainly through urine.

Onset of Action for Netilmicin

within 1 hour.

Duration of Action for Netilmicin

N/A

Half Life of Netilmicin

2 to 2.5 hours

Side Effects of Netilmicin

1.Vestibular damage
2.Ototoxicity
3.Hearing loss
4.Nausea
5.Vomiting
6.Allergic manifestations
7.Nephrotoxicity

Contra-indications of Netilmicin

1. Hypersensitive to the drug or other amino glycosides
2. Renal impairment
3. Labyrinthine disorders

Special Precautions while taking Netilmicin

1.Renal impairment:
2.Neuromuscular disorders
3.Dehydration

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

May be used

Indications for Netilmicin

1.Infections caused by sensitive organisms like klebsiella, enterobacter, staphylococci etc.
2.Urinary tract infections
3.Skin ulcers
4.In neutropenic patients
5.Respiratory infections
6.Burn infections
7.Infections caused by Gentamicin resistant strains

Interactions for Netilmicin

Aminoglycosides, vancomycin, methoxyflurane, enflurane, cephaloridine: Increased nephrotoxicity.
Loop diuretics: The auditory toxicity appears to be increased.
Polypeptide antibiotics: Concurrent use of these agents may increase risk of respiratory paralysis and renal dysfunction.
Anaesthetics, neuromuscular blocking agents (Tubocurarine, Gallamine): Risk of neuromuscular blockade and respiratory paralysis.
Pencillin, cephalosporins, carbenicillin, ticarcillin: Exert antibiotic synergism, especially useful in psuedomonas infections.
Lab tests: Aminoglycoside serum level: Guard against in vitro inactivation of aminoglycosides by beta-lactum antibiotics in patients on combination therapy.

Typical Dosage for Netilmicin

Adults: 4 to 6 mg/kg/day in 1 to 3 divided doses. In severe infections dose may be increased up to 7.5mg/kg/day in 3 divided doses.
Children: 5.5 to 8 mg/kg/day in 2 - 3 divided doses.
Neonates: 4 to 6.5 mg/kg/day in 2 divided doses.
Urinary tract infections: 1.5 to 2mg/day in 2 divided doses.

Schedule of Netilmicin

Storage Requirements for Netilmicin

Store at 15 - 30 degree C in a tightly closed container. Protect away from heat and light. Keep out of the reach of children.

Effects of Missed Dosage of Netilmicin

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose

Effects of Overdose of Netilmicin

Give supportive measures and treatment. An overdose results in Ototoxicity, nephrotoxicity, neuromuscular disorders & hypersensitivity manifestations. Treatment includes removal of drug by dialysis, & drug treatment with neostigmine, Ca, & Prednisolone.

Home Delivery for Netilmicin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including netilmicin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for netilmicin and other medicines and health products. Home delivery services for netilmicin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take netilmicin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for netilmicin before they complete the sale. You can get this information while placing the order for netilmicin with the pharmacy.

Netilmicin is a generic medicine name and there are several brands available for it. Some of the brands for netilmicin might be better known than netilmicin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have netilmicin in stock, you can ask for one of the branded alternatives for netilmicin.