Streptomycin Pharmacology


About Streptomycin
Aminoglycoside Antibiotic, Antitubercular Agent.
Mechanism of Action of Streptomycin
Streptomycin exerts it`s bactericidal action against gram- negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1. Penetration of bacterial cell membrane & binding directly to the 30 S subunit of bacterial ribosome, 2. misleading of m-RNA codon by bacterial ribosome, 3. Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters it`s permeability, 4. Bacterial cell lysis.
Pharmacokinets of Streptomycin
Absorption: Poorly absorbed orally, but well absorbed intra muscularly., Distribution: Distributed extracellularly, Metabolism: Not metabolized, Excretion: Excreted through urine.
Onset of Action for Streptomycin
Duration of Action for Streptomycin
8 hours
Half Life of Streptomycin
2.5 hours
Side Effects of Streptomycin
1. Damage to 8th cranial nerve & Ototoxicity
2. Rashes, Eosinophilia, Drug fever
3. Neuromuscular blockade
4. Nausea, Vomiting
5. Super infection with Candida & Staphylococcus aureus
6. Some degree of nephrotoxicity

Contra-indications of Streptomycin
1.Hypersensitivity to amino glycosides
2.Labyrinthine disorders
3.Never administer I.V
4.Never use along with tetracycline & chloramphenicol
5.never use along with other nephrotoxic drugs
Special Precautions while taking Streptomycin
1. Renal impairment
2. Neuromuscular disorders

Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Streptomycin
5.Enterococcal endocarditis
Interactions for Streptomycin
Aminoglycosides, Amphotericin B, Bacitracin, Cisplatin, Cephalothin, Vancomycin, Methoxyflurane Ethacrynic Acid, Frusemide, Bumetanide & Mannitol: Increased ototoxic, neurotoxic or nephrotoxic affects.
Anaesthetics, Neuromuscular blocking agents (Tubocurarine, Gallamine): Risk of neuromuscular blockade and respiratory paralysis.
Penicillin, Cephalosporins, Carbenicillin, Ticarcillin: Exert antibiotic synergism, especially useful in Pseudomonas infections.
Lab tests: Aminoglycoside serum levels: Guard against in-vitro inactivation of aminoglycosides by b-lactum antibiotics in patients on combination therapy.
Typical Dosage for Streptomycin
0.5 to 1gm daily; Given intramuscularly.
Adults: 15 mg/kg /day for three months then continue the therapy with same dose twice or thrice in a week
Children: 20 to 30 mg /kg/day in divided doses.
1gm daily for 21 days along with tetracycline.
1 to 2gm IM for a week or more.
30mg/kg/day twice daily for 10 days. For better results streptomycin is combined with tetracycline or chloramphenicol
Enterococcal infections:
1gm twice daily for two weeks; then 500mg twice daily for four weeks

Schedule of Streptomycin
Storage Requirements for Streptomycin
keep cool & protect from light
Effects of Missed Dosage of Streptomycin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Streptomycin
Symptoms include allergic manifestations, Ototoxicity, Nephrotoxicity, Neuromuscular toxicity. Treatment include Dialysis, Administration of Prednisolone, Ca salts and Anticholinesterase like neostigmine.

Home Delivery for Streptomycin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including streptomycin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for streptomycin and other medicines and health products. Home delivery services for streptomycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take streptomycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for streptomycin before they complete the sale. You can get this information while placing the order for streptomycin with the pharmacy.

Streptomycin is a generic medicine name and there are several brands available for it. Some of the brands for streptomycin might be better known than streptomycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have streptomycin in stock, you can ask for one of the branded alternatives for streptomycin.