Roxithromycin Pharmacology


About Roxithromycin
It is a semi-synthetic macrolide, Antibiotic.
Mechanism of Action of Roxithromycin
Roxithromycin is a semi synthetic long acting macrolide antibiotic. It binds to the 50S sub unit of bacterial ribosome and inhibits they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.
Pharmacokinets of Roxithromycin
Absorption: Roxithromycin is absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form. Metabolism: small portion undergo metabolism.
Excretion: It is primarily excreted through bile and also excreted through urine and breast milk
Onset of Action for Roxithromycin
1 - 2 hours
Duration of Action for Roxithromycin
8 - 12 hours
Half Life of Roxithromycin
Side Effects of Roxithromycin
1. Nausea
2. Vomiting
3. Diarrhoea
4. Epigastric pain
5. Fever
6. Rash
7. Urticaria
8. Increase in liver enzyme concentrations
Contra-indications of Roxithromycin
1. Hypersensitivity to Roxithromycin and other macrolide
2. Use of ergotamine type compound along with Roxithromycin
Special Precautions while taking Roxithromycin
1. Hepatic dysfunction
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Roxithromycin
1. Pneumonia
2. Tonsilitis
3. Pharyngitis
4. Bronchitis
5. ENT infection
6. Tetanus
7. Diphtheria
8. Sinusitis
9. Gonorrhea
10. Wound and burn infection
11. Skin and soft tissue infections
12. Pertusis
13. Urogenital infection
Interactions for Roxithromycin
Digoxin: Increases absorption.
Midazolam: Increases its half-life.
Terfenadine: Serum levels elevated leading to ventricular arrhythmias.
Disopyramide: Displaced from its protein bound sites.
Typical Dosage for Roxithromycin
Adult: 300 mg in two divided dose for 1 - 2 week
Children: 4 - 8 mg/kg body weight/day in divided dose
Schedule of Roxithromycin
Storage Requirements for Roxithromycin
Store in a cool dark place. Keep away from heat and moisture.
Effects of Missed Dosage of Roxithromycin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Roxithromycin
Give supportive measures and treatment

Home Delivery for Roxithromycin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including roxithromycin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for roxithromycin and other medicines and health products. Home delivery services for roxithromycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take roxithromycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for roxithromycin before they complete the sale. You can get this information while placing the order for roxithromycin with the pharmacy.

Roxithromycin is a generic medicine name and there are several brands available for it. Some of the brands for roxithromycin might be better known than roxithromycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have roxithromycin in stock, you can ask for one of the branded alternatives for roxithromycin.