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- Pharmacology For Erythromycin + Bromhexine
Erythromycin + Bromhexine Pharmacology
Erythromycin + Bromhexine
About Erythromycin + BromhexineN/AMechanism of Action of Erythromycin + BromhexineN/APharmacokinets of Erythromycin + BromhexineN/AOnset of Action for Erythromycin + BromhexineN/ADuration of Action for Erythromycin + BromhexineN/AHalf Life of Erythromycin + BromhexineN/ASide Effects of Erythromycin + BromhexineN/AContra-indications of Erythromycin + BromhexineN/ASpecial Precautions while taking Erythromycin + BromhexineN/APregnancy Related InformationContraindicated; Since Bromhexine is contraindicated during pregnancy the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Bromhexine is contraindicated during Breast feeding the combination generic cannot be used in Breast feedingChildren Related InformationN/AIndications for Erythromycin + Bromhexine1.Bronchitis
2.Pharyngitis
3.Laryngitis
4.PneumoniaInteractions for Erythromycin + BromhexineN/ATypical Dosage for Erythromycin + Bromhexine1tablet to be taken 3 times daily.Schedule of Erythromycin + BromhexineN/AStorage Requirements for Erythromycin + BromhexineN/AEffects of Missed Dosage of Erythromycin + BromhexineN/AEffects of Overdose of Erythromycin + BromhexineN/AErythromycin
About ErythromycinMacrolide Antibiotic.Mechanism of Action of ErythromycinErythromycin is a member of macrolide antibiotics. It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Pharmacokinets of ErythromycinAbsorption: The buffered form of erythromycin is completely absorbed.Distribution: It is widely distributed in the body in protein bound form.Metabolism: small portion undergo metabolism to inactive compound.Excretion: It is primarily excreted through bile and also through urine and breast milk.Onset of Action for Erythromycin2 - 4 hourDuration of Action for Erythromycin8 - 12 hourHalf Life of Erythromycin1 - 2 hourSide Effects of Erythromycin1.Nausea
2.Vomiting
3.Diarrhea
4.Epigastric pain
5.Fever
6.Rash
7.Urticaria
8.Super infection
9.Dryness
10.Pruritis
11.Cholestatic jaundice
12.Hearing disturbances (Ototoxicity)
Contra-indications of Erythromycin1.Hypersensitivity to erythromycin and other macrolide
2.Liver disease
Special Precautions while taking Erythromycin1.Renal impairment
2.Hepatic dysfunction
3.Arrhythmia
4.Heart failure
Pregnancy Related InformationUse with caution.Old Age Related InformationMay be used.Breast Feeding Related InformationUse with caution.Children Related InformationN/AIndications for Erythromycin1.Tonsilitis
2.Pharyngitis
3.Pneumonia
4.Diphtheria
5.Pertusis
6.Tetanus
7.SABE
8.Syphilis
9.Gonorrhea
10.Wound and burn infection
11.Rheumatic fever
12.Acne
13.Urogenital infection
14.Chancroid
15.Intestinal amoebiasis
16.Skin and soft tissue infections
17.Urethritis
Interactions for ErythromycinAnticoagulants: Efficacy enhanced leading to haemorrhages.
Bromocriptine: Efficacy protentiated leading to toxicity.
Carbamazepine: Dangerous toxic side effects requiring resuscitative measures and hospitalisation.
Digoxin: Serum levels of digoxin enhanced, leading to toxicity.
Disopyramide: Increased disopyramide plasma levels leading to arrhythmias.
Ergot Alkaloids: Acute ergotism manifested as peripheral ischaemia.
Methylprednisolone: Decreases methylprednisolone clearance.
Penicillins: Alters efficacy, may be synergistic or antagonist.
Theophylline: Increased serum theophylline levels resulting in toxicity. Decreased serum levels of erythromycin.
Triozolam: Increased CNS depression.Typical Dosage for ErythromycinAdult: 250 - 500 mg every 6 hours
Pneumonia: 250 - 500 mg four times daily for 2 - 3 weeks
Diphtheria: 500 mg four times daily for 1 - 2 weeks
Pertusis: 2 g /day in four divided dose for 2 weeks
Chancroid, Urogenital infections: 500 mg every 6 hours for 1 week
Urethritis: 500 mg orally four times a day for 7 days
Children: 30 - 60 mg/kg body weight/day in 4 divided dose
Pnumonia: 50 mg/kg body weight/day in four divided dose for 3 week
Conjunctivitis: 50 mg/ kg body weight/day in four divided dose for 2 week
Schedule of ErythromycinN/AStorage Requirements for ErythromycinStore in a cool dark place. Keep away from heat and moisture.Effects of Missed Dosage of ErythromycinTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of ErythromycinGive supportive measures and treatmentBromhexine
About BromhexineMucolytic (secretolytic)Mechanism of Action of BromhexineBromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.Pharmacokinets of BromhexineAbsorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.Onset of Action for BromhexineN/ADuration of Action for BromhexineN/AHalf Life of Bromhexine12hours.Side Effects of Bromhexine1 Rhinorrhoea
2 Lacrimations
3.Allergic reactions
4.Gastric irritation.Contra-indications of BromhexineHypersensitivity to the drug.Special Precautions while taking Bromhexine1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Bromhexine1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.Interactions for BromhexineN/ATypical Dosage for BromhexineOral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.
Schedule of BromhexineHStorage Requirements for BromhexineStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of BromhexineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BromhexineProvide symptomatic treatment and supportive measures.Home Delivery for Erythromycin + Bromhexine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including erythromycin + bromhexine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for erythromycin + bromhexine and other medicines and health products. Home delivery services for erythromycin + bromhexine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take erythromycin + bromhexine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for erythromycin + bromhexine before they complete the sale. You can get this information while placing the order for erythromycin + bromhexine with the pharmacy.
Erythromycin + Bromhexine is a generic medicine name and there are several brands available for it. Some of the brands for erythromycin + bromhexine might be better known than erythromycin + bromhexine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have erythromycin + bromhexine in stock, you can ask for one of the branded alternatives for erythromycin + bromhexine.
