Oxytetracycline Pharmacology


About Oxytetracycline
Tetracycline derivative, A broad spectrum antibiotic.
Mechanism of Action of Oxytetracycline
Oxytetracycline is a broad spectrum antibiotic which has action against both gram positive organisms & gram negative organisms. It exerts its bacteriostatic action by accumulating inside the bacteria through specific transporter protein & inhibits bacterial protein synthesis by attaching to 30 S subunit of bacterial ribosome (which are absent in mammals).Oxytetracycline interfering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and peptide chain fails to grow. It chelates cations like Ca & Mg and inhibits functioning of various enzymes & ribosome.
Pharmacokinets of Oxytetracycline
Absorption: Absorbed orally, Distribution: widely distributed; Excretion: excreted through urine & bile
Onset of Action for Oxytetracycline
3 hours
Duration of Action for Oxytetracycline
12 hours
Half Life of Oxytetracycline
8 hours
Side Effects of Oxytetracycline
2.Visual disturbances
3. Intracranial hypertension
4.Aggravates renal & hepatic impairment
8.Epigastric distress
9.Super infection
10.Skin rashes
14.Elevated liver enzymes
15.Discoloration of teeth & Enamel Hypoplasia
16.Retardation of bone growth
17.Esophageal ulceration
Contra-indications of Oxytetracycline

Hypersensitivity to tetracyclines
Special Precautions while taking Oxytetracycline
1.Renal impairment
2.Hepatic impairment
3.Diabetes mellitus
6.Avoid use together with milk & milk products, Antacids, Cations, Vitamins, Products which contain divalent or trivalent cations,
7.Potentiation of action of anticoagulants; so avoid use together.
Pregnancy Related Information
Old Age Related Information
Used with caution
Breast Feeding Related Information
Children Related Information
Neonates: Contraindicated
Indications for Oxytetracycline
2.Ophthalmic infections
3. Rickettsial infections
6.Sexually transmitted diseases like syphilis, gonorrhea, Chancroid
7.Urinogenital tract infections
8.In Lympho granuloma veneram
9.Gastrointestinal tract infections
Interactions for Oxytetracycline
Typical Dosage for Oxytetracycline
Oral: 250mg to 500mg four times daily
Injection: Maximum 250 mg in 24 hours in 2 or 3 divided doses.
Children (above 8 years):
Oral: 25 to 50mg/kg/day thrice daily

Schedule of Oxytetracycline
Storage Requirements for Oxytetracycline
Store in a cool place.
Effects of Missed Dosage of Oxytetracycline
Take the missed dose whenever remember. If it is the time of next dose avoid that dose; because over dosage leads to toxicity.
Effects of Overdose of Oxytetracycline
Treatment is supportive & symptomatic. Gastric lavage & administration of antacids as soon as possible

Home Delivery for Oxytetracycline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including oxytetracycline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for oxytetracycline and other medicines and health products. Home delivery services for oxytetracycline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take oxytetracycline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for oxytetracycline before they complete the sale. You can get this information while placing the order for oxytetracycline with the pharmacy.

Oxytetracycline is a generic medicine name and there are several brands available for it. Some of the brands for oxytetracycline might be better known than oxytetracycline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have oxytetracycline in stock, you can ask for one of the branded alternatives for oxytetracycline.