Doxycycline + Tizanidine Pharmacology

Doxycycline + Tizanidine

About Doxycycline + Tizanidine
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Mechanism of Action of Doxycycline + Tizanidine
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Pharmacokinets of Doxycycline + Tizanidine
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Onset of Action for Doxycycline + Tizanidine
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Duration of Action for Doxycycline + Tizanidine
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Half Life of Doxycycline + Tizanidine
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Side Effects of Doxycycline + Tizanidine
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Contra-indications of Doxycycline + Tizanidine
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Special Precautions while taking Doxycycline + Tizanidine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Doxycycline + Tizanidine
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Interactions for Doxycycline + Tizanidine
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Typical Dosage for Doxycycline + Tizanidine
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Schedule of Doxycycline + Tizanidine
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Storage Requirements for Doxycycline + Tizanidine
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Effects of Missed Dosage of Doxycycline + Tizanidine
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Effects of Overdose of Doxycycline + Tizanidine
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Doxycycline

About Doxycycline
Tetracycline Derivative, Antibiotic.
Mechanism of Action of Doxycycline
Doxycycline is a broad spectrum antibiotic which acts against both gram positive and gram negative organisms. It exerts its bacteriostatic action by accumulating inside the bacteria through specific transporter protein and by passive diffusion & inhibits bacterial protein synthesis by attaching to 30 S subunit of bacterial ribosome (which are absent in mammals).Doxycycline interfering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and peptide chain fails to grow. It chelates cations like Ca &Mg and inhibits functioning of various enzymes & ribosome.
Doxycycline is used in some areas for the treatment of Chloroquine-resistant falciparum malaria
Pharmacokinets of Doxycycline
Absorption: Orally well absorbed, food has not much effect on absorption.
Distribution: Widely distributed; shows protein- binding.
Metabolism: Not substantially metabolized inside the body.
Excretion: Primarily excreted through faeces. Some drug is present in breast milk & a portion is excreted through urine.
Onset of Action for Doxycycline
4 to 12 hours
Duration of Action for Doxycycline
24 hours
Half Life of Doxycycline
18 to 24 hours
Side Effects of Doxycycline
1. Photo toxicity
2. Intracranial hypertension
3. Dysphagia
4. Nausea
5. Vomiting
6. Epigastric distress
7. Super infection
8. Skin rashes
9. Pericarditis
10. Neutropenia
11. Elevated liver enzymes
12. Discoloration of teeth
13. Esophageal ulceration
14. Glossitis
15. Thrombocytopenia
16. Retardation of bone growth
Contra-indications of Doxycycline
1. Hypersensitivity to the drug or other tetracyclines
Special Precautions while taking Doxycycline
1.Renal impairment
2.Hepatic impairment
3.Sun exposure may leads to photo toxicity.
4.Alcohol uptake may decrease antibiotic effect.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES : Contraindicated
Indications for Doxycycline
1. Syphilis
2. Lympho granuloma veneram
3. Typhus fever
4. Respiratory tract infections
5. Prophylaxis of malaria
6. Urinogenital tract infections
7. Trachoma
8. Pelvic inflammatory diseases
9. Acne
10. Diarrhoea
11. Gonorrhea in penicillin allergic individuals
12. Pneumonia
13. Rickettsial infections
14. Urethritis
15. Anthrax
Interactions for Doxycycline
Antacids (aluminium, calcium zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of tetracyclines thus reducing its efficacy.
Anticoagulants: Increase the hypothrombinemic effects of anticoagulants.
Cimetidine: Decreases GI absorption leading to decreased efficacy of tetracyclines.
Digoxin: Increased serum levels leading to digoxin toxicity.
Methoxyflurane: Nephrotoxic effects of both increased.
Oral contraceptives: Breakthrough bleeding, pregnancy due to decreased efficacy.
Penicillins: Efficacy reduced.
Food: Dairy products decrease efficacy of tetracyclines.
Lab Tests: Bacteriosuppressive levels of Demeclocycline persist in both urine and blood for several days after cessation of therapy interfering with culture studies.

Typical Dosage for Doxycycline
Adults: 0.2gm initial dose followed by 0.1gm once daily.
In severe infections: 0.1gm 12 hourly up to 10 days.
Malaria: 200 mg daily for at least 7 days after treatment with quinine.
Malaria prophylaxis: Doxycycline 100 mg daily.
Anthrax: 200 mg / day in 2 divided doses
Acne: 100mg/day Or 50mg twice daily.
Urethritis: 100 mg twice a day for 7 days
Children (above 8 years of age): 3 to 5 mg/kg/day in two divided doses.


Schedule of Doxycycline
H
Storage Requirements for Doxycycline
Store in a cool place.
Effects of Missed Dosage of Doxycycline
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Doxycycline
Treatment is supportive & symptomatic. Drug can be removed by gastric lavage.

Tizanidine

About Tizanidine
A centrally acting a-2 adrenergic agonist, Centrally acting muscle relaxant (short-acting).
Mechanism of Action of Tizanidine
This drug is a centrally acting alpha2 agonist at alpha2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. This results the blocking of nerve impulses (or pain sensations) that are sent to your brain.
Pharmacokinets of Tizanidine
Absorption- Completely absorbed after oral administration.
Distribution- Widely distributed throughout the body. 30% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted through urine.
Onset of Action for Tizanidine
1 to 2 hrs after oral administration
Duration of Action for Tizanidine
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Half Life of Tizanidine
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Side Effects of Tizanidine
1. Dizziness
2. Upset stomach
3. Vomiting
4. Tingling sensation in the arms, legs, hands, and feet
5. Dry mouth
6. Increased muscle spasms
7. Yellowing of the skin or eyes
8. Unexplained flu-like symptoms
Contra-indications of Tizanidine
1. Contraindicated in patients with hypersensitivity to the drug or any ingredients of it
Special Precautions while taking Tizanidine
1. Kidney disease
2. Liver disease
3. Low blood pressure or are on medication to treat high blood pressure
4. Birth control pills use
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Tizanidine
1. Painful muscle spasm associated with static and functional disorders of the spine
2. Following surgery for disc prolapse/osteoarthritis of the hip
Interactions for Tizanidine
Alcohol & other CNS depressants : CNS effects of tizanidine potentiated.
Typical Dosage for Tizanidine
Oral-
Adult-
Muscle spasm - 2 mg thrice a day.
Spasticity- Initial dose 6 mg/day in 3 divided doses, then increase stepwise to 12-36 mg/day.
Schedule of Tizanidine
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Storage Requirements for Tizanidine
Store at room temperature away from moisture and heat.
Effects of Missed Dosage of Tizanidine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tizanidine
Give symptomatic and supportive treatment.

Home Delivery for Doxycycline + Tizanidine in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for doxycycline + tizanidine and other medicines and health products. Home delivery services for doxycycline + tizanidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take doxycycline + tizanidine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for doxycycline + tizanidine before they complete the sale. You can get this information while placing the order for doxycycline + tizanidine with the pharmacy.

Doxycycline + Tizanidine is a generic medicine name and there are several brands available for it. Some of the brands for doxycycline + tizanidine might be better known than doxycycline + tizanidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have doxycycline + tizanidine in stock, you can ask for one of the branded alternatives for doxycycline + tizanidine.