- Medicine India
- Generic Medicines
- T
- Pharmacology For Trimethoprim + Sulfamoxole
Trimethoprim + Sulfamoxole Pharmacology
Trimethoprim + Sulfamoxole
About Trimethoprim + SulfamoxoleN/AMechanism of Action of Trimethoprim + SulfamoxoleN/APharmacokinets of Trimethoprim + SulfamoxoleN/AOnset of Action for Trimethoprim + SulfamoxoleN/ADuration of Action for Trimethoprim + SulfamoxoleN/AHalf Life of Trimethoprim + SulfamoxoleN/ASide Effects of Trimethoprim + SulfamoxoleN/AContra-indications of Trimethoprim + SulfamoxoleN/ASpecial Precautions while taking Trimethoprim + SulfamoxoleN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Trimethoprim + SulfamoxoleN/AInteractions for Trimethoprim + SulfamoxoleN/ATypical Dosage for Trimethoprim + SulfamoxoleN/ASchedule of Trimethoprim + SulfamoxoleN/AStorage Requirements for Trimethoprim + SulfamoxoleN/AEffects of Missed Dosage of Trimethoprim + SulfamoxoleN/AEffects of Overdose of Trimethoprim + SulfamoxoleN/ATrimethoprim
About TrimethoprimDihydrofolate reductase inhibitor, Pyrimidine derivative, Anti-infective(bacteriostatic antibiotic).Mechanism of Action of TrimethoprimTrimethoprim is a bacteriostatic antibiotic and acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleosides thymidine and uridine. Bacteria are unable to take up folic acid from the environment and are thus dependent on their own de novo synthesis.Pharmacokinets of TrimethoprimAbsorption:It is rapidly and completely absorbed after oral administration.Distribution:It is widely distributed in the body.Half of the drug is distributed in protein bound form.Metabolism:About 20% is metabolised in the liver.Excretion:Most of the drug is excreted in urine.Onset of Action for TrimethoprimN/ADuration of Action for TrimethoprimN/AHalf Life of Trimethoprim8 - 11 hoursSide Effects of Trimethoprim1.Loss of appetite
2.Nausea
3.Vomiting
4.Diarrhoea
5.Abdominal pain
6.Abnormal taste
7.Swelling of the tongue.
Contra-indications of Trimethoprim1.Hypersensitivity to Trimethoprim
2.Megaloblastic anaemia caused by folate deficiencySpecial Precautions while taking Trimethoprim1.Renal impairment
2.Hepatic impairment
3.Folate deficiency
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Below 2 years:ContraindicatedIndications for Trimethoprim1.Urinary tract infections
2.Traveler`s diarrhea
3.Respiratory Infection
Interactions for TrimethoprimN/ATypical Dosage for Trimethoprim200 mg/day in 2 divided doses for 10 daysSchedule of TrimethoprimN/AStorage Requirements for TrimethoprimStore at 15 - 30 degree C.Protect from heat,light and moisturiser.Keep out of the reach of children.Effects of Missed Dosage of TrimethoprimTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of TrimethoprimGive supportive measures and symptomatic treatment.Drug can be removed from the body by gastric lavage.Sulfamoxole
About SulfamoxoleIntermediate-acting Sulfonamide, Antibiotic.Mechanism of Action of SulfamoxoleSulfamoxole is an intermediate acting sulfonamide which exerts it`s bacteriostatic action by acting as an antimetabolite by inhibiting bacterial folic acid synthesis. Para amino benzoic acid (PABA) is a constituent of bacterial folic acid. Sulfonamides are structural analogues of PABA & thus inhibits enzyme bacterial
Folate synthetase. It competitively inhibits the union of PABA with pteridine residue to form dihydropteroic acid which conjugates with glutamic acid to produce dihydrofolic acid. Also being chemically similar to PABA the sulfonamides may itself incorporated to form an altered folate which is metabolically injurious
Pharmacokinets of SulfamoxoleAbsorption: Well absorbed orally, Distribution: Widely distributed, Metabolism: Acetylated in liver, Excretion: Excreted through urine.Onset of Action for SulfamoxoleN/ADuration of Action for Sulfamoxole8 to 12 hoursHalf Life of SulfamoxoleN/ASide Effects of Sulfamoxole1.Crystalluria
2.Nausea
3.Vomiting
4.Epigastric pain
5.Rashes
6.Urticaria
7.Drug fever
8.Kernicterus in infants
9.Thrombocytopenia
10.Leucopenia
11.Eosinophilia
12.Hypoglycaemia
13.Hypothyroidism
14.Haematuria
15.Oliguria
16.Anuria
17.Lumbar pain
Contra-indications of Sulfamoxole1.Hypersensitivity to sulfonamides
2.Renal impairment
3.Hepatic impairment
4.Porphyria
5.S.L.E.
Special Precautions while taking Sulfamoxole1.Renal impairment
2.Hepatic impairment
3.Blood dyscrasias
4.G6PD deficiency
5.AIDS
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationAbove 2 months: May be used
Neonates: Contraindicated
Indications for Sulfamoxole1.Meningitis
2.Septicemia
3.Otitismedia
4.Tonsillitis
5.Respiratory tract infections
6.Gastrointestinal tract infections
7.Urinogenitaltract infections
8.Skin infections
Interactions for SulfamoxoleN/ATypical Dosage for SulfamoxoleAdults: 1gm orally twice daily for first day or first two days & then 500mg twice daily.
In severe infections: 1gm thrice daily
Children: Initial dose: 50 to 60mg/kg/day followed by 25 to 30 mg/kg thrice daily
Maximum dose: 75mg/kg/day
Schedule of SulfamoxoleHStorage Requirements for SulfamoxoleStore at cool dry place. Keep out of the reach of children.Effects of Missed Dosage of SulfamoxoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SulfamoxoleGive supportive measures and symptomatic treatment. Home Delivery for Trimethoprim + Sulfamoxole in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including trimethoprim + sulfamoxole.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for trimethoprim + sulfamoxole and other medicines and health products. Home delivery services for trimethoprim + sulfamoxole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take trimethoprim + sulfamoxole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for trimethoprim + sulfamoxole before they complete the sale. You can get this information while placing the order for trimethoprim + sulfamoxole with the pharmacy.
Trimethoprim + Sulfamoxole is a generic medicine name and there are several brands available for it. Some of the brands for trimethoprim + sulfamoxole might be better known than trimethoprim + sulfamoxole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have trimethoprim + sulfamoxole in stock, you can ask for one of the branded alternatives for trimethoprim + sulfamoxole.
