Vancomycin Pharmacology


About Vancomycin
A tricyclic glycopeptide antibiotic.
Mechanism of Action of Vancomycin
Vancomycin binds to the terminal dipeptide sequence of peptidoglycan and inhibits the association and cross linking of peptidoglycan and as the result inhibit cell wall synthesis.
Pharmacokinets of Vancomycin
Absorption: It is well absorbed after parenteral administration.
Distribution: It is very widely distributed in the body.
Excretion: It is excreted through urine.
Onset of Action for Vancomycin
Within minute
Duration of Action for Vancomycin
6 - 8 hours
Half Life of Vancomycin
4 - 6 hours
Side Effects of Vancomycin
1. Thrombophlebitis
2. Pain at the site of injection
3. Fever
4. Necrosis
5. Chills
6. Urticaria
7. Rashes
8. Flushing
9. Neutropenia
10. Oototoxicity
Contra-indications of Vancomycin
1.Hypersensitive to Vancomycin
Special Precautions while taking Vancomycin
1. Renal impairment
2. Hepatic dysfunction
3. Hearing problems
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: Use with caution
Indications for Vancomycin
1. Endocarditis
2. Pseudomembranous enterocolitis
3. Methicillin resistant Staphylococcus aureus infection
4. Staphylococcal enterocolitis
Interactions for Vancomycin
Anion-exchange resins: Antagonism of oral vancomycin by cholestyramine.
Aminoglycosides: Risk of nephrotoxicity may be increased.
Anaesthetics: Erythema and histamine like flushing in children.
Nondepolorizing Muscle Relaxants: The neuromuscular blockade may be enhanced.

Typical Dosage for Vancomycin
Adult (IV dose):500 mg every four times a day
Enterocolitis (oral) 0.5 - 2 g / day in four divided dose for 10 days
Children :( IV dose) 40 mg /kg body weight / day in four divided dose
Neonates: Initial dose: 15mg / kg followed by 20 mg / kg body weight /day in two divided dose for 1 week and then in three divided dose up to 1 month.
Schedule of Vancomycin
Storage Requirements for Vancomycin
Store in room temperature. Keep away from moisture and light.
Effects of Missed Dosage of Vancomycin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vancomycin
Give supportive treatment and measures. Maintain glomerular filtration rate. Then if needed haemodialysis or haemoperfusion can be done.

Home Delivery for Vancomycin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including vancomycin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for vancomycin and other medicines and health products. Home delivery services for vancomycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take vancomycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for vancomycin before they complete the sale. You can get this information while placing the order for vancomycin with the pharmacy.

Vancomycin is a generic medicine name and there are several brands available for it. Some of the brands for vancomycin might be better known than vancomycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have vancomycin in stock, you can ask for one of the branded alternatives for vancomycin.