Polymyxin B Pharmacology

Polymyxin B

About Polymyxin B

Basic polypeptide(Polymyxin)antibiotic, Antibiotic.

Mechanism of Action of Polymyxin B

Polymixin B is a member of poly peptide antibiotic. Being poly peptide they exert a detergent like effect. They have high affinity for phospholipids. Peptide molecules orient between these phospholipids and cause cell membrane distortion and amino acids and ions come out with in the cell.Polymixin B is useful against gram negative bacteria only.

Pharmacokinets of Polymyxin B

Absorption: It is well absorbed after parenteral administration.Distribution: It is very widely distributed in the body.Metabolism: It does not undergo significant metabolism.Excretion: It is excreted mainly through urine.

Onset of Action for Polymyxin B

N/A

Duration of Action for Polymyxin B

N/A

Half Life of Polymyxin B

6 hours.

Side Effects of Polymyxin B

1.Pain at the site of injection
2.Nystagmus
3.Flushing
4.Nausea
5.vomiting
6.Diarrhoea
7.Rash
8.Partial deafness
9. Pruritis
10.Ataxia
11.Vertigo
12.Nephrotoxicity
13.Disturbances of vision

Contra-indications of Polymyxin B

1. Hypersensitive to Polymixin B and other polypeptide antibiotic

Special Precautions while taking Polymyxin B

1.Myasthenia gravis
2.Renal dysfunction

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution

Indications for Polymyxin B

1.Skin infection
2.Urinary tract infection
3.Burns
4.Enteric infection

Interactions for Polymyxin B

Aminoglycosides: Concurrent use may increase risk of respiratory paralysis and renal dysfunction.
Non-depolarising muscle relaxants: Neuromuscular blockade may be enhanced.

Typical Dosage for Polymyxin B

Adult :( IV) DOSE: 15000 - 25000 units /kg body weight/day in divided dose for 1 - 2 week
Children (IV) dose: 20000 - 40000 units/kg body weight/day in divided dose.

Schedule of Polymyxin B

Storage Requirements for Polymyxin B

Store the drug at 10 - 30 degree Celsius

Effects of Missed Dosage of Polymyxin B

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.

Effects of Overdose of Polymyxin B

Give supportive measures and sumptomatic treatment.

Home Delivery for Polymyxin B in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including polymyxin b.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for polymyxin b and other medicines and health products. Home delivery services for polymyxin b may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take polymyxin b only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for polymyxin b before they complete the sale. You can get this information while placing the order for polymyxin b with the pharmacy.

Polymyxin B is a generic medicine name and there are several brands available for it. Some of the brands for polymyxin b might be better known than polymyxin b itself. If the pharmacy that's willing to deliver medicines to your home doesn't have polymyxin b in stock, you can ask for one of the branded alternatives for polymyxin b.