Ethambutol Pharmacology

Ethambutol

About Ethambutol

Ethylenediamine derivative, Antitubercular Agent(Cell envelope antibiotic).

Mechanism of Action of Ethambutol

Ethambutol is a bacteriostatic drug.It inhibits arabinogalactan synthesis and interfere mycolic acid incorporation in to the cell wall.

Pharmacokinets of Ethambutol

Absorption: About 70 % of the drug is rapidly absorbed after oral administration.Distribution: It is very widely distributed in the body.Metabolism: It undergoes metabolism in the liver.Excretion:It is excreted mainly through urine and also bile and breast milk.

Onset of Action for Ethambutol

N/A

Duration of Action for Ethambutol

1 day

Half Life of Ethambutol

3 - 4 hour

Side Effects of Ethambutol

1. Optic neuritis
2. Nausea
3. Vomiting
4. Abdominal pain
5. Gastric upset
6. Headache
7. Loss of colour vision
8. Dizziness
9. Mental confusion
10. Hallucination
11. Peripheral neuritis
12. Anaphylactoid reaction
13. Dermatitis
14. Pruritis
15. Thrombocytopenia
16. Malaise

Contra-indications of Ethambutol

1. Optic neuritis
2. Hypersensitivity to Ethambutol
3. Children below 13 years

Special Precautions while taking Ethambutol

1. Renal impairment
2. Diabetic retinopathy
3. Eye inflammation
4. Gout
5. Cataract

Pregnancy Related Information

Use with caution

Old Age Related Information

N/A

Breast Feeding Related Information

Use with caution

Children Related Information

contraindicated in children below 13 year
NEONATES: contraindicated

Indications for Ethambutol

Pulmonary tuberculosis in category 1 & 2 patients

Interactions for Ethambutol

Aluminium salts: Absorption of ethambutol may be delayed or reduced.

Typical Dosage for Ethambutol

Adult: 15 - 25 mg / kg/ body weight/day depending on the condition of the disease state
Children (above 13 year): 15 - 25 mg / kg/ body weight/day depending on the condition of the disease state.

Schedule of Ethambutol

Storage Requirements for Ethambutol

Ethambutol should be kept in a tightly closed container at room temperature. Keep away from heat and moisture.

Effects of Missed Dosage of Ethambutol

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.

Effects of Overdose of Ethambutol

Give supportive measures and treatment. Induce emesis or gastric lavage followed with charcoal administration.

Home Delivery for Ethambutol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ethambutol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ethambutol and other medicines and health products. Home delivery services for ethambutol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ethambutol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ethambutol before they complete the sale. You can get this information while placing the order for ethambutol with the pharmacy.

Ethambutol is a generic medicine name and there are several brands available for it. Some of the brands for ethambutol might be better known than ethambutol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ethambutol in stock, you can ask for one of the branded alternatives for ethambutol.