Ethionamide Pharmacology


About Ethionamide
Thiocarbamide derivative, Antitubercular Agent(Antibiotic).
Mechanism of Action of Ethionamide
Ethionamide is bactericidal or bacteriostatic depending on the concentration at the site of infection or the susceptibility of the organism.Ethionamide inhibits mycolic acid synthesis and inhibits cell wall formation.
Pharmacokinets of Ethionamide
Absorption: It is well absorbed after oral administration.Distribution: It is widely distributed in the body. Metabolism: It undergoes metabolism in the liver to produce active sulfoxide metabolite and inactive metabolite.Excretion: It is excreted mainly through urine.
Onset of Action for Ethionamide
0.5 - 1 hour
Duration of Action for Ethionamide
12-16 hours.
Half Life of Ethionamide
2 - 3hour
Side Effects of Ethionamide
1. Nausea
2. Vomiting
3. Diarrhoea
4. Skin rash
5. Alopecia
6. Anorexia
7. Mental depression
8. Blurred vision
9. Peripheral neuritis
Contra-indications of Ethionamide
1. Hypersensitivity to Ethionamide
2. Hepatic disease
Special Precautions while taking Ethionamide
1.Psychiatric illness
2.Diabetic patients
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Ethionamide
2. Leprosy
3. MAC(Mycobacterium Avium Copmple)
Interactions for Ethionamide
No known interactions.
Typical Dosage for Ethionamide
Adult: 250 - 500 mg two times daily.
Leprosy: 15 - 20 mg / kg body weight / day;Maximum daily dose 1g
Children: 10 - 20 mg / kg body weight / day in two divided dose.
Leprosy: 12 - 15 mg / kg body weight / day; Maximum daily dose 750 mg
Schedule of Ethionamide
Storage Requirements for Ethionamide
The drug should be kept at 15 - 30 degree Celsius.
Effects of Missed Dosage of Ethionamide
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Ethionamide
Give supportive measures and treatment.

Home Delivery for Ethionamide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ethionamide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ethionamide and other medicines and health products. Home delivery services for ethionamide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ethionamide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ethionamide before they complete the sale. You can get this information while placing the order for ethionamide with the pharmacy.

Ethionamide is a generic medicine name and there are several brands available for it. Some of the brands for ethionamide might be better known than ethionamide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ethionamide in stock, you can ask for one of the branded alternatives for ethionamide.