Clofazimine Pharmacology


About Clofazimine
A fat-soluble riminophenazine bright-red dye , Anti-bacterial, antileprosy agent.
Mechanism of Action of Clofazimine
Clofazimine is a dye which acts as an antileprotic agent & has some anti inflammatory properties also. It acts by interfering with template function of DNA
Pharmacokinets of Clofazimine
Absorption: Absorbed orally, Distribution: It has affinity for fatty tissues & RES(reticulo endothelial system). Metabolism: It is partially metabolized in the body, Excretion: Excreted primarily through bile.
Onset of Action for Clofazimine
Below 1 month
Duration of Action for Clofazimine
Half Life of Clofazimine
Side Effects of Clofazimine
4.Epigastric distress
6.Weight loss
7.Abdominal pain
8.Reddish black discoloration of skin
9.Discoloration of hair & body secretions
14.Pigmentation of conjunctiva &cornea due to crystal deposition
17.Impaired taste
21.Increased blood sugar
22.Increased ESR
Contra-indications of Clofazimine
1.Hypersensitivity to the drug
Special Precautions while taking Clofazimine
1.Hepatic impairment:
2.Renal impairment
3.Patients with gastrointestinal problems
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Clofazimine
1.Multibacillary leprosy
2.Dapsone resistant lepromatous leprosy
3.Skin ulcers
4.Erythema nodosum leprosm
5.Mycobacterium infections in immunocompromised individuals
Interactions for Clofazimine
Rifampicin: Decreases the rate of absorption of rifampicin.
Typical Dosage for Clofazimine
Multi bacillary leprosy: 300mg once a month and 50 mg daily both along with other drugs.
Dapsone resistant leprosy: 100mg/day along with other antileprotic drugs for 3 years followed by Clofazimine 100mg alone daily.
Erythema nodosum leprosm: 100mg to200mg daily reduced to100mg daily
Mycobacterium infections in immunocompromised individuals: 100 to 200mg daily up to 300mg
Type 2 lepra reactions: Up to 300mg/day for <3months.
Children (10 to 14 years): 150mg once a month and 50 mg on alternative days
Schedule of Clofazimine
Storage Requirements for Clofazimine
Store at room temperature. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Clofazimine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clofazimine
Give supportive measures and symptomatic treatment.Drug can be removed from the body by inducing emesis or by gastric lavage.

Home Delivery for Clofazimine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clofazimine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clofazimine and other medicines and health products. Home delivery services for clofazimine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clofazimine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clofazimine before they complete the sale. You can get this information while placing the order for clofazimine with the pharmacy.

Clofazimine is a generic medicine name and there are several brands available for it. Some of the brands for clofazimine might be better known than clofazimine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clofazimine in stock, you can ask for one of the branded alternatives for clofazimine.