Amphotericin-B Pharmacology


About Amphotericin-B
It is a polyene antifungal antibiotic.
Mechanism of Action of Amphotericin-B
Amphotericin B has high affinity for ergosterol present in the fungal cell membrane and bind with it and they orients in such a way that micropore channel are formed and leads to efflux of ions, amino acid, sugar and other water soluble substances and results in cell disruption.
Pharmacokinets of Amphotericin-B
Absorption: It is well absorbed after parenteral administration.Distribution: It is distributed in the body in protein bound form.Metabolism: It undergoes metabolism in the liver.Excretion: It is excreted mainly through urine
Onset of Action for Amphotericin-B
1 minute
Duration of Action for Amphotericin-B
2 days
Half Life of Amphotericin-B
15 days
Side Effects of Amphotericin-B
1.Pain at the site of injection
7.Hearing loss
9.Anaphylactoid reactions
Contra-indications of Amphotericin-B
1.Hypersensitivity to Amphotericin B
Special Precautions while taking Amphotericin-B
1.Renal impairment,
2. Hepatic dysfunction
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution.
Children Related Information
Indications for Amphotericin-B
1.Oral, Cutaneous, vaginal candidiasis
3.Mucocutaneous candidiasis
4.Fungal meningitis
5.Kala azar
13.Systemic mycoses
Interactions for Amphotericin-B
Corticosteroids: Hypokalaemia.
Digitalis: Enhances digitalis toxicity.
Cyclosporine, Aminoglycosides: Increase in nephrotoxic effects.
Betoconazole: Antagonism with betoconazole.
Flucytosine: Synergy.
Typical Dosage for Amphotericin-B
Adult: Initial dose: 1 mg IV; Next day 0.25 mg / kg. / Day followed by an increase in dose of 5 - 10 mg every day. Maximum daily dose: 1 mg / kg body weight / day
Schedule of Amphotericin-B
Storage Requirements for Amphotericin-B
The vial should be stored in refrigerator at 2 - 8 degree C.Keep away from heat and light. The reconstituted solution should be stored in refrigerator and it is stable only for 1 week and when it kept it room temperature it should be used with in a day.
Effects of Missed Dosage of Amphotericin-B
Effects of Overdose of Amphotericin-B
Give supportive measures and treatment.

Home Delivery for Amphotericin-B in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including amphotericin-b.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for amphotericin-b and other medicines and health products. Home delivery services for amphotericin-b may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take amphotericin-b only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for amphotericin-b before they complete the sale. You can get this information while placing the order for amphotericin-b with the pharmacy.

Amphotericin-B is a generic medicine name and there are several brands available for it. Some of the brands for amphotericin-b might be better known than amphotericin-b itself. If the pharmacy that's willing to deliver medicines to your home doesn't have amphotericin-b in stock, you can ask for one of the branded alternatives for amphotericin-b.