Itraconazole Pharmacology


About Itraconazole
A synthetic triazole derivative, Systemic Antifungal.
Mechanism of Action of Itraconazole
Itraconazole is a fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis in fungi.
Pharmacokinets of Itraconazole
Absorption: It is well absorbed when taken with food. Distribution: It is distributed in the body in protein bound form Metabolism: It extensively undergoes metabolism in the liver. Excretion: It is excreted in urine
Onset of Action for Itraconazole
Duration of Action for Itraconazole
Half Life of Itraconazole
31 hour
Side Effects of Itraconazole
8.Decreased libido
Contra-indications of Itraconazole
1.Hypersensitivity to Itraconazole and other Azole antifungals
Special Precautions while taking Itraconazole
1.Hepatic dysfunction
2.Heart failure
Pregnancy Related Information
Old Age Related Information
Used with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Itraconazole
4.Oropharyngeal candidiasis
5.Oesopharyngeal candidiasis
6.Vaginal candidiasis
10.Tinea pedis
11.Tinea corporis
12.Tinea versicolor
13.Tinea cruris
Interactions for Itraconazole
Typical Dosage for Itraconazole
Adult: 100 - 200 mg once or twice daily; duration of therapy varies from 1 day to 6 months
Aspergillosis: 200 - 400 mg once daily for 2 weeks
Oropharyngeal candidiasis: 200 mg in 20 ml solution daily for 7 - 14 days
Oesophageal candidiasis: 100 mg in 10 ml solution daily for 21 days
Onychomycosis: 200 mg once daily for 90 days
Vulvovaginal candidiasis: 400 mg / day in two divided dose for 1 day

Schedule of Itraconazole
Storage Requirements for Itraconazole
The drug should be stored in room temperature. Keep away from moisture and sunlight.
Effects of Missed Dosage of Itraconazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.
Effects of Overdose of Itraconazole
Give supportive measures and symptomatic treatment.

Home Delivery for Itraconazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including itraconazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for itraconazole and other medicines and health products. Home delivery services for itraconazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take itraconazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for itraconazole before they complete the sale. You can get this information while placing the order for itraconazole with the pharmacy.

Itraconazole is a generic medicine name and there are several brands available for it. Some of the brands for itraconazole might be better known than itraconazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have itraconazole in stock, you can ask for one of the branded alternatives for itraconazole.