Fluconazole + Ornidazole Pharmacology

Fluconazole + Ornidazole

About Fluconazole + Ornidazole
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Mechanism of Action of Fluconazole + Ornidazole
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Pharmacokinets of Fluconazole + Ornidazole
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Onset of Action for Fluconazole + Ornidazole
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Duration of Action for Fluconazole + Ornidazole
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Half Life of Fluconazole + Ornidazole
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Side Effects of Fluconazole + Ornidazole
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Contra-indications of Fluconazole + Ornidazole
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Special Precautions while taking Fluconazole + Ornidazole
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Fluconazole + Ornidazole
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Interactions for Fluconazole + Ornidazole
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Typical Dosage for Fluconazole + Ornidazole
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Schedule of Fluconazole + Ornidazole
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Storage Requirements for Fluconazole + Ornidazole
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Effects of Missed Dosage of Fluconazole + Ornidazole
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Effects of Overdose of Fluconazole + Ornidazole
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Fluconazole

About Fluconazole
A triazole derivative, A board range Antifungal.
Mechanism of Action of Fluconazole
Fluconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis
Pharmacokinets of Fluconazole
Absorption: It is well absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: It undergoes insignificant metabolism. Excretion: It is excreted mainly through urine.
Onset of Action for Fluconazole
N/A
Duration of Action for Fluconazole
1 day
Half Life of Fluconazole
N/A
Side Effects of Fluconazole
1.Abdominal pain
2.Nausea
3.Vomiting
4.Diarrhoea
5.Alopecia
6.Headache
7.Rash
8.Alteration in liver enzyme

Contra-indications of Fluconazole
1.Hypersensitivity to Fluconazole and other Azole antifungals
Special Precautions while taking Fluconazole
1. Hepatic dysfunction
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
CHILDREN below13:Use with caution.
NEONATES:contraindicated
Indications for Fluconazole
1.Oesophageal candidiasis
2.Oropharyngeal candidiasis
3.Vaginal candidiasis
4.Systemic candidiasis
5.Cryptococcal meningitis
6.Coccidioidomycosis
7.Histoplasmosis
8.Prophylaxis in bone marrow transplantation
9.Candidiasis in immunocompromised individuals
10.Peritonitis
Interactions for Fluconazole
Cimetidine: Decreased efficacy of fluconazole.
Cyclosporine: Increase in serum cyclosporine plasma concentration.
Hydrochlorothiazide: Reduction in renal clearance of fluconazole.
Phenytoin: Efficacy of phenytoin enhanced.
Rifampicin: Efficacy of fluconazole decreased, higher dosage required.
Sulfonylureas: Efficacy of tolbutamide, glyburide and glipizide increased.
Warfarin: Potentiates the anticoagulant effect resulting in increase in prothrombin time.

Typical Dosage for Fluconazole
Adult: 200 - 400 mg once daily
Systemic candidiasis: Maximum dose: 400 mg .The drug should be administered 2 more weeks after resolution of symptoms.
Oropharyngeal candidiasis: Initial dose: 200 mg once daily followed by 100 mg once daily. The drug should be administered at least 14 days after resolution of symptoms.
Oesophageal candidiasis: Initial dose: 200 mg once daily followed by 100 mg once daily and dose can be increased to 400 mg. The drug should be administered at least 14 days after resolution of symptoms.
Cryptococcal Meningitis: : Initial dose: 400 mg once daily followed by 200 mg once daily for 2 - 3 month until CSF culture is negative.
Vaginal candidiasis: 150 mg once daily
Peritonitis: 50 - 200 mg once daily.
Before bone marrow transplantation as prophylaxis:400 mg once daily for several days before transplantation and after 7 days after Neutrophil count rises above 1000 cells per cub.mm.
Candidiasis in immunocompromised individuals: 100 -200 mg once daily.
CHILDREN:
2 - 8 mg / kg body weight /day
Systemic candidiasis: 6 - 12 mg / kg body weight /day
Oropharyngeal candidiasis: Initial dose: 6 mg / kg body weight / day followed by 3 mg / kg body weight / day. The drug should be administered at least 14 days after resolution of symptoms.

Schedule of Fluconazole
N/A
Storage Requirements for Fluconazole
The drug should be stored in room temperature. Keep away from moisture and sunlight.
Effects of Missed Dosage of Fluconazole
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule.
Effects of Overdose of Fluconazole
Give supportive measures and treatment.

Ornidazole

About Ornidazole
A nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.
Mechanism of Action of Ornidazole
Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of Ornidazole
Absorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for Ornidazole
Within 2 hours
Duration of Action for Ornidazole
14hours
Half Life of Ornidazole
12 to 14 hours
Side Effects of Ornidazole
1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.Vertigo
Contra-indications of Ornidazole
1.Hypersensitivity to the drug or other imidazoles
Special Precautions while taking Ornidazole
1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related Information
Use with caution
First trimester: contra indicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
Indications for Ornidazole
1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for Ornidazole
N/A
Typical Dosage for Ornidazole
Amoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of Ornidazole
H
Storage Requirements for Ornidazole
Store at cool dry place. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Ornidazole
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ornidazole
Treatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics.

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Fluconazole + Ornidazole is a generic medicine name and there are several brands available for it. Some of the brands for fluconazole + ornidazole might be better known than fluconazole + ornidazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluconazole + ornidazole in stock, you can ask for one of the branded alternatives for fluconazole + ornidazole.