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- Pharmacology For Satranidazole + Ofloxacin
Satranidazole + Ofloxacin Pharmacology
Satranidazole + Ofloxacin
About Satranidazole + OfloxacinN/AMechanism of Action of Satranidazole + OfloxacinN/APharmacokinets of Satranidazole + OfloxacinN/AOnset of Action for Satranidazole + OfloxacinN/ADuration of Action for Satranidazole + OfloxacinN/AHalf Life of Satranidazole + OfloxacinN/ASide Effects of Satranidazole + OfloxacinN/AContra-indications of Satranidazole + OfloxacinN/ASpecial Precautions while taking Satranidazole + OfloxacinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Satranidazole + OfloxacinN/AInteractions for Satranidazole + OfloxacinN/ATypical Dosage for Satranidazole + OfloxacinN/ASchedule of Satranidazole + OfloxacinN/AStorage Requirements for Satranidazole + OfloxacinN/AEffects of Missed Dosage of Satranidazole + OfloxacinN/AEffects of Overdose of Satranidazole + OfloxacinN/ASatranidazole
About SatranidazoleNitroimidazole derivative, Anti-protozoal.Mechanism of Action of SatranidazoleSatranidazole is nitro imidazoles which have broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3.DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of SatranidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver, Excretion: Excreted in urine.
Onset of Action for SatranidazoleN/ADuration of Action for Satranidazole12 hoursHalf Life of Satranidazole14 hoursSide Effects of Satranidazole1.Headache
2.Dizziness
3.Dry mouth
4.Weakness
Contra-indications of Satranidazole1.Hypersensitivity to the drug
2.Blood dyscrasias
Special Precautions while taking SatranidazoleN/APregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Neonates: Contraindicated
Indications for Satranidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
Interactions for SatranidazoleAlcohol: It does not produce any disulfiram-like reaction with alcohol.Typical Dosage for SatranidazoleAmoebiasis:
300mg 12hourly for 5 days
Giardiasis and Trichomoniasis:
600mg as a single dose
Schedule of SatranidazoleHStorage Requirements for SatranidazoleStore in a well closed container and protect from light. Keep out of the reach of children.Effects of Missed Dosage of SatranidazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of SatranidazoleTreatment is supportive & symptomatic. Ofloxacin
About OfloxacinA second generation fluoroquinolone(quinolones), Antibiotic.Mechanism of Action of OfloxacinOfloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of OfloxacinAbsorption: Ofloxacin is rapidly and completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Onset of Action for OfloxacinWith in 0.5 hour Duration of Action for Ofloxacin12 - 16 hoursHalf Life of Ofloxacin5 - 8 hoursSide Effects of Ofloxacin1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Constipation
6. Dry mouth
7. Dizziness
8. Headache
9. Rash
10. Pruritis
11. Pseudomembranous colitis
12. Visual disturbances
13. Insomnia
Contra-indications of Ofloxacin1. Hypersensitivity to Ofloxacin and other FluoroquinolonesSpecial Precautions while taking Ofloxacin1. Hepatic impairment
2. Renal impairment
3. Cerebral arteriosclerosis
4. Epilepsy
5. CNS disease
6. Avoid exposure to sunlight
7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Ofloxacin1. Bronchitis
2. Pneumonia
3. Urinary tract infection
4. Bone and joint infections
5. Intra-abdominal infections
6. Gonorrhoea
7. ENT infections
8. Skin and soft tissue infections
9. Typhoid fever
10. Prostatis
11. Otitis
12. Gynaecological infections
13. Conjunctivitis
14. Keratitis
15. Urethritis
16. CervicitisInteractions for OfloxacinOral Anticoagulants: The effects of oral anticoagulants, may be increased.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAID`s: CNS excitation may occur.Typical Dosage for OfloxacinAdults: 200 - 400 mg / day depending on the severity and type of infection
Bronchitis, Pneumonia, Skin and soft tissue infections: 800 mg / day in 2 divided doses for 10 days
Gonorrhoea: 400 mg as a single dose.
Prostatis, Cervicitis & Urethritis: 600 mg / day in 2 divided doses for 1 week.
UTI: 200 - 800 mg / day in single or divided doses
Typhoid fever: 400 - 800 mg / day in 2 divided doses
Schedule of OfloxacinHStorage Requirements for OfloxacinStore at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of OfloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of OfloxacinGive supportive measures and symptomatic treatment. Gastric lavage has to be done. Home Delivery for Satranidazole + Ofloxacin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including satranidazole + ofloxacin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for satranidazole + ofloxacin and other medicines and health products. Home delivery services for satranidazole + ofloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take satranidazole + ofloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for satranidazole + ofloxacin before they complete the sale. You can get this information while placing the order for satranidazole + ofloxacin with the pharmacy.
Satranidazole + Ofloxacin is a generic medicine name and there are several brands available for it. Some of the brands for satranidazole + ofloxacin might be better known than satranidazole + ofloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have satranidazole + ofloxacin in stock, you can ask for one of the branded alternatives for satranidazole + ofloxacin.
