Furazolidone Pharmacology


About Furazolidone
A nitro furan derivative, Antibacterial,Antiprotozoal.
Mechanism of Action of Furazolidone
Furazolidone is a nitro furan which is employed as a broad spectrum bactericidal agent the actual mechanism of action is not clear. But it is known that it interfere with several bacterial enzyme systems. They have effects on DNA and bring about various changes in bacteria & also have radiomimetic & mutagenic properties
Pharmacokinets of Furazolidone
Absorption: It is partially absorbed orally
Excretion: It is excreted in urine
Onset of Action for Furazolidone
Duration of Action for Furazolidone
Half Life of Furazolidone
Side Effects of Furazolidone
1. Dizziness
2. Headache
3. Nausea
4. Vomiting
5. Decreased B.P
6. Deafness with tinnitus
7. Urticaria
8. Fever
9. Arthralgia
10. Disulfiram like reactions with alcohol.
Contra-indications of Furazolidone
1. Hypersensitivity
2. Along with alcohol
Special Precautions while taking Furazolidone
1. Use cautiously in G6PD deficiency
2. Urine colour turns orange which has no clinical significance
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Neonates : Contraindicated
Indications for Furazolidone
1. Bacterial diarrhoea
2. Protozoal diarrhoea
3. Enteritis
4. Giardiasis
5. Trichomoniasis
6. Food poisoning
7. Infections caused by salmonella shigella etc.
8. Bacterial and monilial vaginitis
Interactions for Furazolidone
Alcohol: Disulfiram like reaction-facial flushing,light headedness, weakness, lacrimation.
Anorexiants: Increased pressor response of anorexiants due to MAO inhibition.
Levodopa: Both efficacy and adverse effects of levodopa increased especially hypertensive crisis. Effect lasts for several weeks after stopping furazolidone.
Sympathomimetics (indirect & mixed): Increased pressor sensitivity to these agents due to MAO inhibition.
TCAs: Hypertension, hyperpyrexia, seizures, tachycardia, acute psychosis.
Hypnotics & Sedatives: Dose of hypnotics and sedatives should be reduced.
Hypoglycaemics: Potentiates them.
Food: Hypertensive crisis with tyramine containing foods.

Typical Dosage for Furazolidone
Adults: 100mg 6 hourly 2 to 7 days depending up on the severity of infections
Children: 1.25 mg 6 hourly for 2 to 5 days & up to 10days for Giardiasis
Schedule of Furazolidone
Storage Requirements for Furazolidone
Store at controlled room temperature at a range of 15 to 30 degree C. in a well closed container and protects from light.
Effects of Missed Dosage of Furazolidone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Furazolidone
Treatment is supportive and symptomatic.

Home Delivery for Furazolidone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including furazolidone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for furazolidone and other medicines and health products. Home delivery services for furazolidone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take furazolidone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for furazolidone before they complete the sale. You can get this information while placing the order for furazolidone with the pharmacy.

Furazolidone is a generic medicine name and there are several brands available for it. Some of the brands for furazolidone might be better known than furazolidone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have furazolidone in stock, you can ask for one of the branded alternatives for furazolidone.