Metronidazole + Diloxanide Furoate Pharmacology

Metronidazole + Diloxanide Furoate

About Metronidazole + Diloxanide Furoate
N/A
Mechanism of Action of Metronidazole + Diloxanide Furoate
N/A
Pharmacokinets of Metronidazole + Diloxanide Furoate
N/A
Onset of Action for Metronidazole + Diloxanide Furoate
N/A
Duration of Action for Metronidazole + Diloxanide Furoate
N/A
Half Life of Metronidazole + Diloxanide Furoate
N/A
Side Effects of Metronidazole + Diloxanide Furoate
N/A
Contra-indications of Metronidazole + Diloxanide Furoate
N/A
Special Precautions while taking Metronidazole + Diloxanide Furoate
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Metronidazole + Diloxanide Furoate
N/A
Interactions for Metronidazole + Diloxanide Furoate
N/A
Typical Dosage for Metronidazole + Diloxanide Furoate
N/A
Schedule of Metronidazole + Diloxanide Furoate
N/A
Storage Requirements for Metronidazole + Diloxanide Furoate
N/A
Effects of Missed Dosage of Metronidazole + Diloxanide Furoate
N/A
Effects of Overdose of Metronidazole + Diloxanide Furoate
N/A

Metronidazole

About Metronidazole
A nitroimidazole antibiotic, Anti-infective, Antiprotozoal,amebicide.
Mechanism of Action of Metronidazole
Metronidazole is nitro imidazoles which have broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which exerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization & strand breakage has been observed.
Pharmacokinets of Metronidazole
Absorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by oxidation & glucuronide conjugation, Excretion: Excreted in urine.
Onset of Action for Metronidazole
1 to 2 days
Duration of Action for Metronidazole
8hours.
Half Life of Metronidazole
8 hours.
Side Effects of Metronidazole
1.Anorexia.
2.Metallic taste
3.Nausea
4.Vomiting
5.Diarrhoea
6.Headache
7.Looseness of stool.
8.Peripheral neuropathy &CNS effects.
9.Mutagenesis.
10.Radiosensitisation.
11.Transient leucopenia
12.Dry mouth
13.Abdominal distress
14.Dizziness
15.Vertigo
16.Thrombophlebitis at site of injection
17.Ototoxicity
Contra-indications of Metronidazole
1.Hypersensitivity to the drug
2.Blood dyscrasias
3.CNS disorders
Special Precautions while taking Metronidazole
1.Renal impairment
2.Hepatic impairment
3.Alcoholic cirrhosis
4.Use cautiously along with other hepatotoxic drugs & In visual field changes
Pregnancy Related Information
Use with caution
First trimester:contra indicated
Old Age Related Information
May be used.
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Neonates: Contraindicated
Indications for Metronidazole
1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Pseudo membranous enterocolitis
5.Anaerobic bacterial infections after surgery, Brain abscess, & Endocarditis
6.Helicobacter pylori infections
7.Ulcerative gingivitis
Interactions for Metronidazole
Warfarin & other coumarin anticoagulants: Potentiates the anticoagulant effect resulting in increased prothrombin time.
Alcohol: A disulfiram-like reaction. Abdominal cramps, nausea, vomiting, headache & flushing.
Disulfiram: Acute psychotic reaction or confusional state.
Phenobarbital & Phenytoin: Increased metabolism of metronidazole resulting in decreased efficacy.
Lithium: Increased lithium levels and toxicity.
Flurouracil: Increased toxicity of flurouracil.
Lab tests: May interfere with chemical analysis for AST,SGOT, ALT, SGPT, LDH, triglycerides and hexokinase glucose. Zero values may occur.
Typical Dosage for Metronidazole
Adult
Amoebiasis:400 to 800 mg 8hourly for 5 to 10days depending up on the severity of infection
In severe infections and liver abscess: 1gm as slow I.V. infusion followed by 0.5 gm twice daily till oral therapy is started
Giardiasis:200mg 8hourly for 1week or 2gm/day for 3days or I.V.500mg thrice daily
Trichomonas vaginitis: 400mg 8 hourly for a week or 2gm once daily for a week.
Male partner should be concurrently treated with the drug
Pseudo membranous enterocolitis:800 mg 8hourly
Anaerobic bacterial infections after surgery, Brain abscess, & Endocarditis:400 to 800 mg 8hourly
In severe cases: 15mg/kg I.V. infusion for 1hour followed by 7.5mg/kg 4 times daily till oral therapy is substituted
Helicobacter pylori infections:400mg 8hourly along with amoxicillin/clarithromycin and a proton pump inhibitor
Ulcerative gingivitis:200 to 800mg 8hourly
Children
Amoebiasis: 30 to 50mg/kg/day for 5to10 days.
Giardiasis:10 to 15mg/kg/day thrice daily
Children (below 12years): 7.5mg/kg I.V.
Schedule of Metronidazole
H
Storage Requirements for Metronidazole
Store in a well closed container in a cool dark place. Keep out of the reach of children.
Effects of Missed Dosage of Metronidazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Metronidazole
Treatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal & use of cathartics. For controlling seizures diazepam & phenytoin may be used.

Diloxanide Furoate

About Diloxanide Furoate
Dichloroacetamide derivative, anti-protozoal, Luminal amebicides.
Mechanism of Action of Diloxanide Furoate
Diloxanide Furoate is a dicloroacetamide derivative which acts as a luminal amoebicide. It exerts its action by directly killing the trophozoites responsible for production of cysts.
Pharmacokinets of Diloxanide Furoate
Absorption: Orally well absorbed.
Metabolism: It is metabolized by glucuronide conjugation.
Excretion: Excreted through urine.
Onset of Action for Diloxanide Furoate
N/A
Duration of Action for Diloxanide Furoate
N/A
Half Life of Diloxanide Furoate
N/A
Side Effects of Diloxanide Furoate
1. Flatulence
2. Nausea
3. Itching
4. Urticaria rashes
Contra-indications of Diloxanide Furoate
N/A
Special Precautions while taking Diloxanide Furoate
1. Hepatic impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below 2 years : Contraindicated
Indications for Diloxanide Furoate
1. Mild intestinal Amoebiasis,
2. Asymptomatic cyst passers of Entamoeba histolitica
Interactions for Diloxanide Furoate
No known interaction.
Typical Dosage for Diloxanide Furoate
Adults: 0.5gm 8hourly for 5 to 10days.
Children (above 2years): 20mg/kg/day in divided doses up to 10days.
Schedule of Diloxanide Furoate
H
Storage Requirements for Diloxanide Furoate
Store in a cool dry place.Protect from heat and light.Keep out of the reach of children.
Effects of Missed Dosage of Diloxanide Furoate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Diloxanide Furoate
Give supportive measures and symptomatic treatment.

Home Delivery for Metronidazole + Diloxanide Furoate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including metronidazole + diloxanide furoate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for metronidazole + diloxanide furoate and other medicines and health products. Home delivery services for metronidazole + diloxanide furoate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take metronidazole + diloxanide furoate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for metronidazole + diloxanide furoate before they complete the sale. You can get this information while placing the order for metronidazole + diloxanide furoate with the pharmacy.

Metronidazole + Diloxanide Furoate is a generic medicine name and there are several brands available for it. Some of the brands for metronidazole + diloxanide furoate might be better known than metronidazole + diloxanide furoate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have metronidazole + diloxanide furoate in stock, you can ask for one of the branded alternatives for metronidazole + diloxanide furoate.