Tinidazole + Diloxanide Furoate + Methyl Polysiloxane Pharmacology

Tinidazole + Diloxanide Furoate + Methyl Polysiloxane

About Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Mechanism of Action of Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Pharmacokinets of Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Onset of Action for Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Duration of Action for Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Half Life of Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Side Effects of Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Contra-indications of Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Special Precautions while taking Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Interactions for Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Typical Dosage for Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Schedule of Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Storage Requirements for Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Effects of Missed Dosage of Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Effects of Overdose of Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
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Tinidazole

About Tinidazole
Nitroimidazole antibiotic, Antibacterial, antiprotozoal.
Mechanism of Action of Tinidazole
Tinidazole is nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. .DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of Tinidazole
Absorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by oxidation &glucuronide conjugation, Excretion: Excreted in urine.
Onset of Action for Tinidazole
Within few hours
Duration of Action for Tinidazole
16 hours
Half Life of Tinidazole
12 hours
Side Effects of Tinidazole
1.Anorexia
2.Bitter taste
3.Nausea
4.Vomiting
5.Diarrhoea
6.Fatigue
7.Dry mouth
8.Abdominal distress
9.Headache
10.Dizziness
11.Vertigo
12.Rash
13.Urticaria
14.Angioedema
15.Peripheral neuropathy & CNS effects,
Contra-indications of Tinidazole
1.Hypersensitivity to the drug
2.Blood dyscrasias
3.CNS disorders
Special Precautions while taking Tinidazole
1.Hepatic impairment
2.Alcoholic cirrhosis
3.Obstructive liver diseases
4. Use cautiously along with other hepatotoxic drugs & In visual field changes
5. Avoid alcohol use during therapy
Pregnancy Related Information
Use with caution, but contra indicated in first trimester
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Tinidazole
1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Prophylactic agent after colorectal surgery
6.H. pylori infections
Interactions for Tinidazole
Alcohol: Disulfiram like reaction.
Ampicillin, Doxycycline and Cotrimoxaole: Synergism with these agents.
Typical Dosage for Tinidazole
Amoebiasis:
Adults: 2gm once daily for 3 days
Children: 30 to 50mg/kg/day or 600mg 12hourly for 5 to 10 days
Trichomoniasis & Giardiasis:
600mg once daily for a week or 2gm single dose
Anaerobic bacterial infections:
2 gm followed by 500mg 12 hourly for 5 days
Prophylaxis after colorectal surgery:
2gm single dose before surgery
H. pylori infections:
0.5gm 12hourly for 7 to14 days in triple combination
Schedule of Tinidazole
H
Storage Requirements for Tinidazole
Store at room temperature at a range of 15 to 30 degree C. Protect from excess heat and moisture.
Effects of Missed Dosage of Tinidazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tinidazole
Treatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. For controlling seizures diazepam & phenytoin may be used

Diloxanide Furoate

About Diloxanide Furoate
Dichloroacetamide derivative, anti-protozoal, Luminal amebicides.
Mechanism of Action of Diloxanide Furoate
Diloxanide Furoate is a dicloroacetamide derivative which acts as a luminal amoebicide. It exerts its action by directly killing the trophozoites responsible for production of cysts.
Pharmacokinets of Diloxanide Furoate
Absorption: Orally well absorbed.
Metabolism: It is metabolized by glucuronide conjugation.
Excretion: Excreted through urine.
Onset of Action for Diloxanide Furoate
N/A
Duration of Action for Diloxanide Furoate
N/A
Half Life of Diloxanide Furoate
N/A
Side Effects of Diloxanide Furoate
1. Flatulence
2. Nausea
3. Itching
4. Urticaria rashes
Contra-indications of Diloxanide Furoate
N/A
Special Precautions while taking Diloxanide Furoate
1. Hepatic impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below 2 years : Contraindicated
Indications for Diloxanide Furoate
1. Mild intestinal Amoebiasis,
2. Asymptomatic cyst passers of Entamoeba histolitica
Interactions for Diloxanide Furoate
No known interaction.
Typical Dosage for Diloxanide Furoate
Adults: 0.5gm 8hourly for 5 to 10days.
Children (above 2years): 20mg/kg/day in divided doses up to 10days.
Schedule of Diloxanide Furoate
H
Storage Requirements for Diloxanide Furoate
Store in a cool dry place.Protect from heat and light.Keep out of the reach of children.
Effects of Missed Dosage of Diloxanide Furoate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Diloxanide Furoate
Give supportive measures and symptomatic treatment.

Methyl Polysiloxane

About Methyl Polysiloxane
Siloxanes, Antiflatulent.
Mechanism of Action of Methyl Polysiloxane
Methyl Polysiloxane relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas.
Pharmacokinets of Methyl Polysiloxane
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Onset of Action for Methyl Polysiloxane
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Duration of Action for Methyl Polysiloxane
N/A
Half Life of Methyl Polysiloxane
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Side Effects of Methyl Polysiloxane
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Contra-indications of Methyl Polysiloxane
Hypersensitivity to Methyl Polysiloxane
Special Precautions while taking Methyl Polysiloxane
Kidney failure
Pregnancy Related Information
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Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Methyl Polysiloxane
1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Methyl Polysiloxane
N/A
Typical Dosage for Methyl Polysiloxane
125 - 166 mg taken half an hour before food.
Methyl Polysiloxane in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Methyl Polysiloxane
Schedule of Methyl Polysiloxane
N/A
Storage Requirements for Methyl Polysiloxane
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Methyl Polysiloxane
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Methyl Polysiloxane
Give symptomatic and supportive treatment.

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