Primaquine Pharmacology


About Primaquine
8-Aminoquinolone compound , Antimalarial.
Mechanism of Action of Primaquine
Primaquine damage the mitochondria; the power house of parasite. With out energy the parasite cannot live
Pharmacokinets of Primaquine
Absorption: It is well absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: It undergoes metabolism in the liver. Excretion: The unchanged drug is excreted through urine.
Onset of Action for Primaquine
1 - 2 hours
Duration of Action for Primaquine
3 - 6 hours
Half Life of Primaquine
3 - 6 hours
Side Effects of Primaquine
1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal cramps
5. Haemolytic anaemia
6. Methhaemoglobinaemia
7. Agranulocytosis
Contra-indications of Primaquine
1. Rheumatoid arthritis
2. Lupus Erythematosus
3. Patients taking bone marrow suppressants
4. Potential use of haemolytic drugs.
Special Precautions while taking Primaquine
1.Methhaemoglobin reductase deficient patients
2.G-6-PD deficiency
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Primaquine
1. Malaria
2. Pneumocystis carinii pneumonia
Interactions for Primaquine
Quinacrine: May potentiate toxicity. Do not administer primaquine to patients who have recently received quinacrine.
Typical Dosage for Primaquine
Adult: 15 mg base daily for 2 weeks
Children: 0.3 mg base /kg body weight /day
Schedule of Primaquine
Storage Requirements for Primaquine
The drug should be stored in cool dark place. Protect away from sun light. Keep out of the reach of children
Effects of Missed Dosage of Primaquine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Primaquine
Give supportive measures and treatment.

Home Delivery for Primaquine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including primaquine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for primaquine and other medicines and health products. Home delivery services for primaquine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take primaquine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for primaquine before they complete the sale. You can get this information while placing the order for primaquine with the pharmacy.

Primaquine is a generic medicine name and there are several brands available for it. Some of the brands for primaquine might be better known than primaquine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have primaquine in stock, you can ask for one of the branded alternatives for primaquine.