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- Pharmacology For Chloroquine + Primaquine
Chloroquine + Primaquine Pharmacology
Chloroquine + Primaquine
About Chloroquine + PrimaquineN/AMechanism of Action of Chloroquine + PrimaquineN/APharmacokinets of Chloroquine + PrimaquineN/AOnset of Action for Chloroquine + PrimaquineN/ADuration of Action for Chloroquine + PrimaquineN/AHalf Life of Chloroquine + PrimaquineN/ASide Effects of Chloroquine + PrimaquineN/AContra-indications of Chloroquine + PrimaquineN/ASpecial Precautions while taking Chloroquine + PrimaquineN/APregnancy Related InformationContraindicated; since Primaquine is contraindicated in pregnancy, the combination generic cannot be used in pregnancyOld Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Primaquine is contraindicated in breast feeding, the combination generic cannot be used in breast feeding mother.Children Related InformationN/AIndications for Chloroquine + PrimaquineMalaria-due to Plasmodium vivaxInteractions for Chloroquine + PrimaquineN/ATypical Dosage for Chloroquine + PrimaquineAdult: Chloroquine 300 mg + Primaquine 45 mg once a week for 10 weekSchedule of Chloroquine + PrimaquineN/AStorage Requirements for Chloroquine + PrimaquineN/AEffects of Missed Dosage of Chloroquine + PrimaquineN/AEffects of Overdose of Chloroquine + PrimaquineN/AChloroquine
About Chloroquine4- Aminoquinoline, excellent schizonticide, Antimalarial, amebicide, anti inflammatory and local irritant.Mechanism of Action of ChloroquineMalarial parasites digest their own haemoglobin and release highly toxic heme. This heme is used up by parasitic polymerase enzyme and converted to non toxic haemozoin.Since Chloroquine is a weak base it has high affinity towards acidic lysosome.Chloroquine inhibits polymerase enzyme and interfere the formation of haemozoin and results in accumulation of toxic haeme and also it binds with haeme to form haeme- Chloroquine complex. These lead to membrane lysis and kill the parasite.Pharmacokinets of ChloroquineAbsorption: It is well absorbed after oral administration.Distribution: It is distributed in protein bound form and concentrated in melanin containing cells.Metabolism: some drugs undergo metabolism in the liver. Excretion: It is excreted mainly through urine.Onset of Action for Chloroquine2 - 3 days Duration of Action for Chloroquine7 daysHalf Life of Chloroquine3 - 10 daysSide Effects of Chloroquine1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal cramps
5.Pruritis
6.Headache
7.Dizziness
8.Hypotension
9.Visual disturbances
Contra-indications of Chloroquine1.Hypersensitivity to Chloroquine and other 4 Amino quinolines
2.Porphyria
3.Retinal damageSpecial Precautions while taking ChloroquineHepatic dysfunction
1.Renal impairment
2.Epilepsy
3.Patients with G -6-PD deficiency
4.Preexisting retinal damage
5.Haematological disorder
6.Gastrointestinal disorder
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Chloroquine1.Malaria
2.Rheumatoid arthritis
3.Extraintestinal amoebiasis
4.Discoid Lupus ErythematosusInteractions for ChloroquineAntacids: Reduced absorption.
Cholinergics: Effects of Neostigmine and pyridostigmine antagonized.
Cimetidine: Inhibits metabolism raising plasma levels.
Pyrimethamine, Sulphadoxine: May cause Steven-Johnson`s Syndrome.
Quinacrine: Increased toxicity with quinacrine.
Phenylbutazone: Predisposes to dermatitis.
Ampicillin: Bioavailability of ampicillin reduced.
Typical Dosage for ChloroquineAdult: Initial dose: 600 mg base; after 6 hours 300 mg base; third and forth dose (300 mg base) is administered after 24 and 48 hours of initial dose.
Rheumatoid arthritis: 250 mg once daily at night
Extraintestinal amoebiasis: 600 mg once daily for 2 days followed by 300 mg once daily for 14 - 21 days
Discoid Lupus Erythematosus: 250 mg once daily at night
Children: Initial dose: 10mg /kg body weight; after 6 hours 5mg /kg body weight; third and forth dose (5mg /kg body weight) is administered after 24 and 48 hours of initial dose.
Schedule of ChloroquineHStorage Requirements for ChloroquineThe drug should be stored in cool dark place. Protect away from sun light. Keep out of the reach of children.Effects of Missed Dosage of ChloroquineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of ChloroquineGive supportive measures and treatment. Induce emesis or gastric lavage has to be done followed by administration of charcoal. To control seizure Thiopentone can be given to the patient. If necessary peritoneal dialysis may be usedPrimaquine
About Primaquine8-Aminoquinolone compound , Antimalarial.Mechanism of Action of PrimaquinePrimaquine damage the mitochondria; the power house of parasite. With out energy the parasite cannot livePharmacokinets of PrimaquineAbsorption: It is well absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: It undergoes metabolism in the liver. Excretion: The unchanged drug is excreted through urine.Onset of Action for Primaquine1 - 2 hoursDuration of Action for Primaquine3 - 6 hoursHalf Life of Primaquine3 - 6 hoursSide Effects of Primaquine1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal cramps
5. Haemolytic anaemia
6. Methhaemoglobinaemia
7. Agranulocytosis
Contra-indications of Primaquine1. Rheumatoid arthritis
2. Lupus Erythematosus
3. Patients taking bone marrow suppressants
4. Potential use of haemolytic drugs.
Special Precautions while taking Primaquine1.Methhaemoglobin reductase deficient patients
2.G-6-PD deficiencyPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: ContraindicatedIndications for Primaquine1. Malaria
2. Pneumocystis carinii pneumonia
Interactions for PrimaquineQuinacrine: May potentiate toxicity. Do not administer primaquine to patients who have recently received quinacrine.Typical Dosage for PrimaquineAdult: 15 mg base daily for 2 weeks
Children: 0.3 mg base /kg body weight /day
Schedule of PrimaquineHStorage Requirements for PrimaquineThe drug should be stored in cool dark place. Protect away from sun light. Keep out of the reach of childrenEffects of Missed Dosage of PrimaquineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of PrimaquineGive supportive measures and treatment.Home Delivery for Chloroquine + Primaquine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including chloroquine + primaquine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for chloroquine + primaquine and other medicines and health products. Home delivery services for chloroquine + primaquine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take chloroquine + primaquine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for chloroquine + primaquine before they complete the sale. You can get this information while placing the order for chloroquine + primaquine with the pharmacy.
Chloroquine + Primaquine is a generic medicine name and there are several brands available for it. Some of the brands for chloroquine + primaquine might be better known than chloroquine + primaquine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have chloroquine + primaquine in stock, you can ask for one of the branded alternatives for chloroquine + primaquine.
