Stavudine Pharmacology

Stavudine

About Stavudine
Nucleoside Reverse Transcriptase Inhibitor, Antiretroviral Agent.
Mechanism of Action of Stavudine
Stavudine is a Thymidine nucleoside analogue. It undergoes phosphorylation in the presence of Kinase enzyme and form Stavudine triphosphate. This Stavudine triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and is then added to host cell chromosome. Stavudine triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication.
Pharmacokinets of Stavudine
Absorption: It is rapidly absorbed after oral administration.
Distribution: It is widely distributed in the body.
Excretion: It is excreted in urine.
Onset of Action for Stavudine
60 minutes
Duration of Action for Stavudine
N/A
Half Life of Stavudine
90 minutes
Side Effects of Stavudine
1. Nausea
2. Vomiting
3. Diarrhoea
4. Anorexia
5. Peripheral neuropathy
6. Thrombocytopenia
7. Neutropenia
8. Lactic acidosis
9. Hepatic steatosis
10.Headache
11 Anaemia
12.Myalgia
13.Rash
14.Dizziness
15.Fever
16.Pruritis
Contra-indications of Stavudine
1. Hypersensitivity to Stavudine
Special Precautions while taking Stavudine
1. Peripheral neuropathy
2. Renal impairment
3. Hepatic impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
NEONATES: Contraindicated
Indications for Stavudine
1. HIV infections
Interactions for Stavudine
N/A
Typical Dosage for Stavudine
Adult: 30 - 40 mg 2 times daily
Patient weighing 60 kg or more: 80 mg / day in 2 divided dose.
Patient weighing 30 - 60 kg: 60 mg / day in 2 divided dose.
Children weighing below 30 kg: 2 mg / kg body weight / day in 2 divided dose
Schedule of Stavudine
H
Storage Requirements for Stavudine
Store it at 15 -25 degree C in a tightly closed container .Protect away from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Stavudine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and do not double the dose
Effects of Overdose of Stavudine
Give supportive measures and treatment.

Home Delivery for Stavudine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including stavudine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for stavudine and other medicines and health products. Home delivery services for stavudine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take stavudine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for stavudine before they complete the sale. You can get this information while placing the order for stavudine with the pharmacy.

Stavudine is a generic medicine name and there are several brands available for it. Some of the brands for stavudine might be better known than stavudine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have stavudine in stock, you can ask for one of the branded alternatives for stavudine.