Lamivudine Pharmacology

Lamivudine

About Lamivudine

Nucleoside Reverse Transcriptase Inhibitor ,cytidine analogue, Antiretroviral.

Mechanism of Action of Lamivudine

Lamivudine is a deoxy cytidine nucleoside analogue. It undergoes phosphorylation in the presence of Kinase enzyme and form Lamivudine triphosphate. This Lamivudine triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and is then added to host cell chromosome. Lamivudine triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication. Lamivudine triphosphate is also a potent inhibitor of HBV (hepatitis B virus)

Pharmacokinets of Lamivudine

Absorption: It is rapidly absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: Metabolism is insignificant. Excretion: It is excreted in urine

Onset of Action for Lamivudine

N/A

Duration of Action for Lamivudine

N/A

Half Life of Lamivudine

5 - 7 hours

Side Effects of Lamivudine

1.Nausea
2.Vomiting
3.Diarrhoea
4.Anorexia
5.Headache
6.Dizziness
7.Anaemia
8.Neutropenia
9.Thrombocytopenia
10.Myalgia
11.Rash
12.Fever

Contra-indications of Lamivudine

Hypersensitivity to Lamivudine

Special Precautions while taking Lamivudine

1.Renal impairment
2.Hepatic dysfunction

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution
NEONATES: contraindicated

Indications for Lamivudine

1.HIV infections
2.Treatment of chronic Hepatitis B

Interactions for Lamivudine

Trimethoprim, sulfamethoxazole: Results in an increase in AUC of Lamivudine and a decrease in renal clearance.
Zidovudine: Results in an increase in C max. of Zidovudine.

Typical Dosage for Lamivudine

Adult: 100 - 300 mg / day in 2 divided dose
HIV infection: 300 mg / day in 2 divided dose
Treatment of chronic Hepatitis B: 100 mg / day
Children: 4 - 8 mg / kg /day in 2 divided dose
HIV infection: 4 mg / kg /day in 2 divided dose

Schedule of Lamivudine

Storage Requirements for Lamivudine

Store it at 15 -25 degree C in a tightly closed container .Protect away from heat and light

Effects of Missed Dosage of Lamivudine

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and do not double the dose

Effects of Overdose of Lamivudine

Give supportive measures and treatment.

Home Delivery for Lamivudine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lamivudine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lamivudine and other medicines and health products. Home delivery services for lamivudine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lamivudine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lamivudine before they complete the sale. You can get this information while placing the order for lamivudine with the pharmacy.

Lamivudine is a generic medicine name and there are several brands available for it. Some of the brands for lamivudine might be better known than lamivudine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lamivudine in stock, you can ask for one of the branded alternatives for lamivudine.