Abacavir Pharmacology

Abacavir

About Abacavir

Reverse Transcriptase Inhibitor (Nucleoside), Antiretroviral Agent.

Mechanism of Action of Abacavir

Abacavir is a guanosine nucleoside analogue. It undergoes phosphorylation in the presence of phosphotransferase and Kinase enzyme and form Carbovir triphosphate. This Carbovir triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and it is then added to host cell chromosome Carbovir triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication.

Pharmacokinets of Abacavir

Absorption: It is rapidly and extensively absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: It undergoes intracellular metabolism to the active antiviral metabolite Carbovir triphosphate. Excretion: It is excreted mainly in urine.

Onset of Action for Abacavir

N/A

Duration of Action for Abacavir

N/A

Half Life of Abacavir

60 - 120 minutes

Side Effects of Abacavir

1.Nausea
2.Vomiting
3.Diarrhoea
4.Anorexia
5.Malaise
6.Fever
7.Pruritis
8.Rash
9.Headache
10.Pharyngitis
11.Cough

Contra-indications of Abacavir

Hypersensitivity to Abacavir

Special Precautions while taking Abacavir

1.Renal impairment
2.Hepatic impairment (Hepatomegaly, Lactic acidosis)

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

May be used
NEONATES: Contraindicated

Indications for Abacavir

HIV infection in combination with other antiretroviral drugs.

Interactions for Abacavir

Analgesics: Plasma concentration of methadone possibly decreased by abacavir.

Typical Dosage for Abacavir

Adult: 600 mg / day in 2 divided doses combine with other antiretroviral agents.
Children: 16 mg / kg body weight / day in 2 divided doses

Schedule of Abacavir

Storage Requirements for Abacavir

Store it at 15 -25 degree C in a tightly closed container .Protect away from heat and light. Keep out of the reach of children.

Effects of Missed Dosage of Abacavir

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule. Do not double the dose.

Effects of Overdose of Abacavir

Give supportive measures and treatment.

Home Delivery for Abacavir in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including abacavir.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for abacavir and other medicines and health products. Home delivery services for abacavir may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take abacavir only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for abacavir before they complete the sale. You can get this information while placing the order for abacavir with the pharmacy.

Abacavir is a generic medicine name and there are several brands available for it. Some of the brands for abacavir might be better known than abacavir itself. If the pharmacy that's willing to deliver medicines to your home doesn't have abacavir in stock, you can ask for one of the branded alternatives for abacavir.