Nevirapine Pharmacology


About Nevirapine
A non-nucleoside reverse transcriptase inhibitor (NNRTI), Antiretroviral.
Mechanism of Action of Nevirapine
Nevirapine noncompetitively binds to a site other than catalytic site in the HIV- 1 reverse transcriptase enzyme .This binding will results in a structural change in the enzyme and inhibits its activity i.e. conversion of viral RNA to pro viral DNA and subsequent virus replication
Pharmacokinets of Nevirapine
Absorption: It is rapidly absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: It is extensively metabolised in the liver
Excretion: The drug is primarily excreted through faeces and it is also excreted through urine.
Onset of Action for Nevirapine
Duration of Action for Nevirapine
Half Life of Nevirapine
30 hours
Side Effects of Nevirapine
1. Rash
2. Stevens-Johnson syndrome
3. Dizziness
4. Headache
5. Fatigue
6. Nausea
7. Diarrhoea
8. Fever
9. Somnolence
Contra-indications of Nevirapine
1. Hypersensitivity to Nevirapine
Special Precautions while taking Nevirapine
1. Renal impairment
2. Hepatic impairment
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Nevirapine
1. HIV-1 infection
Interactions for Nevirapine
Analgesics : Possible reduction in plasma concentration of methadone.
Antibacterials: Rifampicin and Rifabutin reduce plasma concentration of nevirapine
Antidepressants: Plasma concentration of nevirapine reduced by St. John?s Wort.
Other antivirals: Nevirapine reduces plasma concentration of saquinavir also plasma concentration of indinavir and possibly amprenavir and lopinavir.
Oestrogen and progestogens: Reduced contraceptive effect of oral and other hormonal contraceptives.
Typical Dosage for Nevirapine
Adult: 200 mg / day for 2 weeks followed by 400 mg / day in 2 divided doses along with other antiretroviral agents
Children > 2 months: 4 mg / kg body weight / day in single dose for 2 weeks followed by 8 - 14 mg / kg body weight / day in 2 divided doses; depending on the age of the patient the dose is selected by the treating specialist
Maximum daily dose: 400 mg
Schedule of Nevirapine
Storage Requirements for Nevirapine
Store at 15 - 30 degree C in a tightly closed container. Protect away from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Nevirapine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose
Effects of Overdose of Nevirapine
Give supportive measures and treatment.

Home Delivery for Nevirapine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nevirapine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nevirapine and other medicines and health products. Home delivery services for nevirapine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nevirapine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nevirapine before they complete the sale. You can get this information while placing the order for nevirapine with the pharmacy.

Nevirapine is a generic medicine name and there are several brands available for it. Some of the brands for nevirapine might be better known than nevirapine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nevirapine in stock, you can ask for one of the branded alternatives for nevirapine.