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- Pharmacology For Indinavir
IndinavirAbout IndinavirProtease Inhibitor , Antiretroviral Agent.Mechanism of Action of IndinavirIndinavir is a peptide analogue. It reversibly binds to the HIV encoded aspartyl protease enzyme which is involved in the degradation of poly protein into structural protein and subsequent maturation of virus particle. Binding of Indinavir to the enzyme results in immature noninfectious viral progeny
Pharmacokinets of IndinavirAbsorption: It is rapidly absorbed after oral administration. Distribution: About half of the drug is distributed as protein bound form. Metabolism: It undergoes metabolism in the liver. Excretion: The metabolites are excreted through faeces and the parent drug through urine.Onset of Action for Indinavir60 minuteDuration of Action for IndinavirN/AHalf Life of Indinavir90 - 120 minuteSide Effects of Indinavir1. Nausea
4. Abdominal pain
Contra-indications of IndinavirHypersensitivity to IndinavirSpecial Precautions while taking Indinavir1.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
Indications for IndinavirHIV infectionInteractions for IndinavirHMG-CoA reductase inhibitors: Risk of myopathy including rhabdomyolysis.
Rifampin: AUC of indinavir decreased by 89%?9%.
Rifabutin: Efficacy of indinavir reduced.
Ketoconazole: Efficacy of indinavir enhanced.
Grapefruit Juice: Efficacy of indinavir decreased.
Nevirapine: Efficacy of indinavir decreased.
Typical Dosage for IndinavirAdult: 2.4 g / day in 3 equal divided dose; given along with other antiretroviral drugs
Schedule of IndinavirHStorage Requirements for IndinavirStore at 15 - 30 degree C.Protect away from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of IndinavirTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed doseEffects of Overdose of IndinavirGive supportive measures and treatment
Home Delivery for Indinavir in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including indinavir.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for indinavir and other medicines and health products. Home delivery services for indinavir may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take indinavir only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for indinavir before they complete the sale. You can get this information while placing the order for indinavir with the pharmacy.
Indinavir is a generic medicine name and there are several brands available for it. Some of the brands for indinavir might be better known than indinavir itself. If the pharmacy that's willing to deliver medicines to your home doesn't have indinavir in stock, you can ask for one of the branded alternatives for indinavir.