Ribavirin Pharmacology


About Ribavirin
A nucleoside antimetabolite, Triazole derivative, Antiviral.
Mechanism of Action of Ribavirin
Ribavirin is a nucleoside analogue and it is phosphorylated by adenosine kinase enzyme in the host cell to form Ribavirin monophosphate.This will inhibits Inosine monophosphate (IMP) formation and also cause degradation of guanosine triphosphate (GTP) .All these results in inhibition of protein synthesis and suppression of elongation of viral mRNA
Pharmacokinets of Ribavirin
Absorption: It is absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes metabolism and form deribosylated Ribavirin. Excretion: It is excreted mainly through urine.
Onset of Action for Ribavirin
Duration of Action for Ribavirin
Half Life of Ribavirin
30 - 120 minutes
Side Effects of Ribavirin
1. Conjunctivitis
2. Bronchospasm
3. Haemolysis
4. Rash
5. Anaemia
Contra-indications of Ribavirin
1. Hypersensitivity to Ribavirin
Special Precautions while taking Ribavirin
1. Renal impairment
2. Asthma
3. Anaemia
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Ribavirin
1. Respiratory syncytial virus (RSV) infection
2. Influenza A & B virus infection
3. Herpes simplex virus
4. Hepatitis B virus
5. Lassa fever
6. Haemorrhagic fever
7. Measles
8. Para influenza virus infection in children
Interactions for Ribavirin
Typical Dosage for Ribavirin
Adults: 200 mg 3 - 4 times daily
Influenza infection: 800 mg / day in 4 equal divided doses for 5 days
Herpes simplex virus: 800 mg / day in 4 equal divided doses for 1 week
Hepatitis: 800 mg / day in 4 equal divided doses for 2 weeks
Children: 10 mg / kg body weight / day
Schedule of Ribavirin
Storage Requirements for Ribavirin
Store at 15 - 25 degree C in a dry place. Keep out of the reach of children.
Effects of Missed Dosage of Ribavirin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ribavirin
Give supportive measures and symptomatic treatment

Home Delivery for Ribavirin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ribavirin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ribavirin and other medicines and health products. Home delivery services for ribavirin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ribavirin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ribavirin before they complete the sale. You can get this information while placing the order for ribavirin with the pharmacy.

Ribavirin is a generic medicine name and there are several brands available for it. Some of the brands for ribavirin might be better known than ribavirin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ribavirin in stock, you can ask for one of the branded alternatives for ribavirin.