Famciclovir Pharmacology

Famciclovir

About Famciclovir
Nucleosides and Nucleotides :A synthetic acyclic guanine analogue , Antiviral for HSV, Varicella-Zoster.
Mechanism of Action of Famciclovir
Famciclovir is a prodrug and it is converted to active Penciclovir. It undergoes phosphorylation in the presence Thymidine kinase and form Penciclovir monophosphate and it is again phosphorylated by Cellular kinase and form Penciclovir triphosphate. This Penciclovir triphosphate inhibits DNA polymerase enzyme and inhibits DNA synthesis and consequently inhibit viral replication.
Pharmacokinets of Famciclovir
Absorption: It is absorbed after oral administration Distribution: It is widely distributed in the body. Metabolism: It undergoes metabolism and form Penciclovir .Excretion: It is excreted through urine
Onset of Action for Famciclovir
N/A
Duration of Action for Famciclovir
N/A
Half Life of Famciclovir
2 - 3 hour
Side Effects of Famciclovir
1.Nausea
2.Vomiting
3.Burning and stinging
4.Malaise
5.Tremor
6.Hallucinations
7.Lethargy
8.Parasthesia
Contra-indications of Famciclovir
Hypersensitivity to Famciclovir
Special Precautions while taking Famciclovir
1. Renal impairment
2. Hepatic impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Famciclovir
1.Herpes simplex virus infection
2.Herpes zoster and genital herpes infections in immunocompromised patients
Interactions for Famciclovir
Uricosurics: probenicid possibly reduces famciclovir excretion thereby increasing plasma concentration.
Typical Dosage for Famciclovir
Herpes zoster infection in immunocompromised patient: 1.5 g / day in 3divided dose for 1 week
Prophylaxis of herpes simplex virus in immunocompromised patient: 1 g / day in 2 divided dose
Genital herpes in immunocompromised patient: 250 mg / day in 2 divided dose for 5 days
Schedule of Famciclovir
H
Storage Requirements for Famciclovir
Store in airtight container at a temperature of 15- 25 degree C.Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Famciclovir
Take the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose.
Effects of Overdose of Famciclovir
Give supportive measures and symptomatic treatment. Haemodialysis can be used in emergency condition for the removal of drug

Home Delivery for Famciclovir in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including famciclovir.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for famciclovir and other medicines and health products. Home delivery services for famciclovir may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take famciclovir only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for famciclovir before they complete the sale. You can get this information while placing the order for famciclovir with the pharmacy.

Famciclovir is a generic medicine name and there are several brands available for it. Some of the brands for famciclovir might be better known than famciclovir itself. If the pharmacy that's willing to deliver medicines to your home doesn't have famciclovir in stock, you can ask for one of the branded alternatives for famciclovir.