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- Pharmacology For Lamivudine + Stavudine + Nevirapine
Lamivudine + Stavudine + Nevirapine Pharmacology
Lamivudine + Stavudine + Nevirapine
About Lamivudine + Stavudine + NevirapineN/AMechanism of Action of Lamivudine + Stavudine + NevirapineN/APharmacokinets of Lamivudine + Stavudine + NevirapineN/AOnset of Action for Lamivudine + Stavudine + NevirapineN/ADuration of Action for Lamivudine + Stavudine + NevirapineN/AHalf Life of Lamivudine + Stavudine + NevirapineN/ASide Effects of Lamivudine + Stavudine + NevirapineN/AContra-indications of Lamivudine + Stavudine + NevirapineN/ASpecial Precautions while taking Lamivudine + Stavudine + NevirapineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Lamivudine + Stavudine + NevirapineN/AInteractions for Lamivudine + Stavudine + NevirapineN/ATypical Dosage for Lamivudine + Stavudine + NevirapineN/ASchedule of Lamivudine + Stavudine + NevirapineN/AStorage Requirements for Lamivudine + Stavudine + NevirapineN/AEffects of Missed Dosage of Lamivudine + Stavudine + NevirapineN/AEffects of Overdose of Lamivudine + Stavudine + NevirapineN/ALamivudine
About LamivudineNucleoside Reverse Transcriptase Inhibitor ,cytidine analogue, Antiretroviral.Mechanism of Action of LamivudineLamivudine is a deoxy cytidine nucleoside analogue. It undergoes phosphorylation in the presence of Kinase enzyme and form Lamivudine triphosphate. This Lamivudine triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and is then added to host cell chromosome. Lamivudine triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication. Lamivudine triphosphate is also a potent inhibitor of HBV (hepatitis B virus)Pharmacokinets of LamivudineAbsorption: It is rapidly absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: Metabolism is insignificant. Excretion: It is excreted in urineOnset of Action for LamivudineN/ADuration of Action for LamivudineN/AHalf Life of Lamivudine5 - 7 hoursSide Effects of Lamivudine1.Nausea
2.Vomiting
3.Diarrhoea
4.Anorexia
5.Headache
6.Dizziness
7.Anaemia
8.Neutropenia
9.Thrombocytopenia
10.Myalgia
11.Rash
12.FeverContra-indications of LamivudineHypersensitivity to LamivudineSpecial Precautions while taking Lamivudine1.Renal impairment
2.Hepatic dysfunctionPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: contraindicated
Indications for Lamivudine1.HIV infections
2.Treatment of chronic Hepatitis BInteractions for LamivudineTrimethoprim, sulfamethoxazole: Results in an increase in AUC of Lamivudine and a decrease in renal clearance.
Zidovudine: Results in an increase in C max. of Zidovudine.Typical Dosage for LamivudineAdult: 100 - 300 mg / day in 2 divided dose
HIV infection: 300 mg / day in 2 divided dose
Treatment of chronic Hepatitis B: 100 mg / day
Children: 4 - 8 mg / kg /day in 2 divided dose
HIV infection: 4 mg / kg /day in 2 divided dose
Schedule of LamivudineHStorage Requirements for LamivudineStore it at 15 -25 degree C in a tightly closed container .Protect away from heat and lightEffects of Missed Dosage of LamivudineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and do not double the doseEffects of Overdose of LamivudineGive supportive measures and treatment.Stavudine
About StavudineNucleoside Reverse Transcriptase Inhibitor, Antiretroviral Agent.Mechanism of Action of StavudineStavudine is a Thymidine nucleoside analogue. It undergoes phosphorylation in the presence of Kinase enzyme and form Stavudine triphosphate. This Stavudine triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and is then added to host cell chromosome. Stavudine triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication.Pharmacokinets of StavudineAbsorption: It is rapidly absorbed after oral administration.
Distribution: It is widely distributed in the body.
Excretion: It is excreted in urine.
Onset of Action for Stavudine60 minutesDuration of Action for StavudineN/AHalf Life of Stavudine90 minutesSide Effects of Stavudine1. Nausea
2. Vomiting
3. Diarrhoea
4. Anorexia
5. Peripheral neuropathy
6. Thrombocytopenia
7. Neutropenia
8. Lactic acidosis
9. Hepatic steatosis
10.Headache
11 Anaemia
12.Myalgia
13.Rash
14.Dizziness
15.Fever
16.Pruritis
Contra-indications of Stavudine1. Hypersensitivity to StavudineSpecial Precautions while taking Stavudine1. Peripheral neuropathy
2. Renal impairment
3. Hepatic impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationMay be used
NEONATES: Contraindicated
Indications for Stavudine1. HIV infectionsInteractions for StavudineN/ATypical Dosage for StavudineAdult: 30 - 40 mg 2 times daily
Patient weighing 60 kg or more: 80 mg / day in 2 divided dose.
Patient weighing 30 - 60 kg: 60 mg / day in 2 divided dose.
Children weighing below 30 kg: 2 mg / kg body weight / day in 2 divided dose
Schedule of StavudineHStorage Requirements for StavudineStore it at 15 -25 degree C in a tightly closed container .Protect away from heat and light. Keep out of the reach of children.Effects of Missed Dosage of StavudineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and do not double the doseEffects of Overdose of StavudineGive supportive measures and treatment.Nevirapine
About NevirapineA non-nucleoside reverse transcriptase inhibitor (NNRTI), Antiretroviral.Mechanism of Action of NevirapineNevirapine noncompetitively binds to a site other than catalytic site in the HIV- 1 reverse transcriptase enzyme .This binding will results in a structural change in the enzyme and inhibits its activity i.e. conversion of viral RNA to pro viral DNA and subsequent virus replicationPharmacokinets of NevirapineAbsorption: It is rapidly absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: It is extensively metabolised in the liver
Excretion: The drug is primarily excreted through faeces and it is also excreted through urine.
Onset of Action for NevirapineN/ADuration of Action for NevirapineN/AHalf Life of Nevirapine30 hoursSide Effects of Nevirapine1. Rash
2. Stevens-Johnson syndrome
3. Dizziness
4. Headache
5. Fatigue
6. Nausea
7. Diarrhoea
8. Fever
9. Somnolence
Contra-indications of Nevirapine1. Hypersensitivity to NevirapineSpecial Precautions while taking Nevirapine1. Renal impairment
2. Hepatic impairmentPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Nevirapine1. HIV-1 infection
Interactions for NevirapineAnalgesics : Possible reduction in plasma concentration of methadone.
Antibacterials: Rifampicin and Rifabutin reduce plasma concentration of nevirapine
Antidepressants: Plasma concentration of nevirapine reduced by St. John?s Wort.
Other antivirals: Nevirapine reduces plasma concentration of saquinavir also plasma concentration of indinavir and possibly amprenavir and lopinavir.
Oestrogen and progestogens: Reduced contraceptive effect of oral and other hormonal contraceptives.Typical Dosage for NevirapineAdult: 200 mg / day for 2 weeks followed by 400 mg / day in 2 divided doses along with other antiretroviral agents
Children > 2 months: 4 mg / kg body weight / day in single dose for 2 weeks followed by 8 - 14 mg / kg body weight / day in 2 divided doses; depending on the age of the patient the dose is selected by the treating specialist
Maximum daily dose: 400 mg
Schedule of NevirapineHStorage Requirements for NevirapineStore at 15 - 30 degree C in a tightly closed container. Protect away from heat and light. Keep out of the reach of children.Effects of Missed Dosage of NevirapineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed doseEffects of Overdose of NevirapineGive supportive measures and treatment. Home Delivery for Lamivudine + Stavudine + Nevirapine in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lamivudine + stavudine + nevirapine and other medicines and health products. Home delivery services for lamivudine + stavudine + nevirapine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take lamivudine + stavudine + nevirapine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lamivudine + stavudine + nevirapine before they complete the sale. You can get this information while placing the order for lamivudine + stavudine + nevirapine with the pharmacy.
Lamivudine + Stavudine + Nevirapine is a generic medicine name and there are several brands available for it. Some of the brands for lamivudine + stavudine + nevirapine might be better known than lamivudine + stavudine + nevirapine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lamivudine + stavudine + nevirapine in stock, you can ask for one of the branded alternatives for lamivudine + stavudine + nevirapine.
