Mebendazole Pharmacology


About Mebendazole
A benzimidazole derivative, Anthelmintic.
Mechanism of Action of Mebendazole
Mebendazole is a benzimidazole used as a broad spectrum anthelminthic which acts by blocking glucose uptake in the parasite and depletion of its glycogen stores. Intracellular microtubules in the cells of the worm are gradually lost. The drug binds to beta tubulin of susceptible worms with high affinity and inhibits its polymerization. Ascaris ova are killed. It also inhibits hatching of nematode eggs and larvae.
Pharmacokinets of Mebendazole
Absorption: Poorly absorbed orally (5 to 10%)
Distribution: Shows protein binding & crosses placenta
Metabolism: Metabolized in to inactive metabolites
Excretion: Excreted mainly in faeces and also in urine
Onset of Action for Mebendazole
2 to 3 days
Duration of Action for Mebendazole
Half Life of Mebendazole
3 to 9 hours
Side Effects of Mebendazole
1. Headache
2. Transient abdominal pain
3. Diarrhoea
4. Nausea
5. Expulsion of worms
6. Granulocytopenia
7. Rashes
8. Hair loss
9. Fever
10. Dizziness
Contra-indications of Mebendazole
1. Hyper sensitivity to the drug
Special Precautions while taking Mebendazole
1. Monitor blood count during the treatment of Echinococcus granulosus infection
Pregnancy Related Information
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Above 2 years : May be used
Below 2 years : Contraindicated
Indications for Mebendazole
1. Ascariasis
2. Pinworm infection
3. Hook worm infection
4. Tape worm infection
5. Whip worm infections
6. Threadworm infections
7. Hydatid disease
8. Cappillariasis
9. Mixed infestation
Interactions for Mebendazole
Carbamazepine and Hydantoin: Reduce plasma levels of mebendazole thus decreasing its efficacy.
Food: Fatty food enhance absorption of mebendazole.
Typical Dosage for Mebendazole
Adults & Children over 2 years:
Enterobius:100mg single dose, Repeats after 2 to 3 weeks
Round worm, Hook worm and Trichuris:100mg 12hourly for 3days; second course after 14 days if necessary
Tape worm: 0.2gm 12 hourly for 3 days
Trichinella spiralis: 200 to 400mg 12hourly or 8hourly for 3days
Hydatid disease: 200 to 400mg 12hourly or 8hourly for 3 to 4 weeks
Schedule of Mebendazole
Storage Requirements for Mebendazole
Store in a well closed container at a temperature range of 15 to 25 degree Centigrade.
Effects of Missed Dosage of Mebendazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Mebendazole
Treatment is supportive & symptomatic. Empty stomach by induced emesis & gastric lavage; within 4 hours after ingestion. Give activated charcoal to reduce absorption.

Home Delivery for Mebendazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mebendazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mebendazole and other medicines and health products. Home delivery services for mebendazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mebendazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mebendazole before they complete the sale. You can get this information while placing the order for mebendazole with the pharmacy.

Mebendazole is a generic medicine name and there are several brands available for it. Some of the brands for mebendazole might be better known than mebendazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mebendazole in stock, you can ask for one of the branded alternatives for mebendazole.