Levamisole Pharmacology


About Levamisole
Synthetic imidazothiazole derivative, Biological response modifier, Anthelmintic, Antineoplastic adjunct.
Mechanism of Action of Levamisole
Levamisole is the levo isomer of Tetramisole which is used as an anthelminthic agent. It exerts its action by producing paralysis of worm by causing sustained contraction of somatic muscles of worm by an irreversible, noncompetitive depolarization type of Neuro muscular block. It also non competitively inhibits the production of succinate.Its immunostimalant action is by modulating cell mediated immunity by increasing phagocytosis by macrophages. It restores cutaneous delayed hyper sensitivity reactions.
Pharmacokinets of Levamisole
Absorption: Well absorbed orally.
Metabolism: Metabolized inside the body.
Excretion: Excreted through urine.
Onset of Action for Levamisole
Duration of Action for Levamisole
Half Life of Levamisole
Side Effects of Levamisole
1. Headache
2. Dizziness
3. Abdominal pain
4. Diarrhoea
5. Nausea
6. Vomiting
7. Fever
8. Arthralgia
9. Myalgia
10 Impaired taste
Contra-indications of Levamisole
1. Hypersensitivity to the drug
2. Disorders of blood
Special Precautions while taking Levamisole
1. Rheumatoid arthritis
2. Drug causes disulfiram like reaction with alcohol
Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Children Related Information
Indications for Levamisole
1. Ascariasis, Mixed Ascaris,
2. Ancylostomiasis (Hookworm infestation)
3. As Immunomodulator in Cancer patients & in Rheumatoid arthritis
Interactions for Levamisole
Alcohol: Levamisole may produce disulfiram like effects with alcohol.
Phenytoin: Co-administration with levamisole and fluorouracil results in increased serum phenytoin levels.
Typical Dosage for Levamisole
Ascariasis:2.5 to 5mg/kg or 150mg single oral dose.
Ancylostomiasis & Mixed Ascaris, Hookworm infestation: 0.3gm for 1 to 2 days. Alternatively administer 2.5mg/kg as a single dose. Repeat after 1week if required
Ascariasis:3mg/kg or 50mg single oral dose.
Ancylostomiasis & Mixed Ascaris, Hookworm infestation: 6mg/kg for 1 to 2 days
Schedule of Levamisole
Storage Requirements for Levamisole
Store at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of Levamisole
Take the missed dose as soon as remember and If it is the time for next dose then skip the missed dose and take the regular dose.
Effects of Overdose of Levamisole
Treatment is supportive & symptomatic. Empty stomach by gastric lavage.

Home Delivery for Levamisole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including levamisole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for levamisole and other medicines and health products. Home delivery services for levamisole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take levamisole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for levamisole before they complete the sale. You can get this information while placing the order for levamisole with the pharmacy.

Levamisole is a generic medicine name and there are several brands available for it. Some of the brands for levamisole might be better known than levamisole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have levamisole in stock, you can ask for one of the branded alternatives for levamisole.