Praziquantel Pharmacology


About Praziquantel
Anthelmintic, A trematodicide.
Mechanism of Action of Praziquantel
It is a broad spectrum anthelminthic against Trematodes & Cestodes and their larval forms. The drug exerts its action by producing strong muscular contractions which leads to paralysis. The drug also causes tegumental vesicle formation causing the parasite to detach from the wall of the vein, intestine or tissues.
Pharmacokinets of Praziquantel
Absorption: Well absorbed orally but undergoes first pass metabolism. Distribution: The drug attains therapeutic concentration in brain Metabolism: Metabolized in liver. Excretion: Excreted mainly through urine.
Onset of Action for Praziquantel
Duration of Action for Praziquantel
Half Life of Praziquantel
1 to 1.5 hours
Side Effects of Praziquantel
1. Nausea
2. Vomiting
3. Diarrhea
4. Abdominal pain
5. Headache
6. Dizziness
7. Sedation
8. Rashes
9. Urticaria
10. Itching
11. Fever
12. Body pain
Contra-indications of Praziquantel
1.Hyper sensitivity to the drug
2.Do not breast feed up to 3 days after drug treatment
3.Ocular Cysticercosis
Special Precautions while taking Praziquantel
1.Hepatic impairment
2.Avoid driving or other jobs requiring consciousness for 24 hour after treatment
Pregnancy Related Information
Contraindicated in first trimester
Old Age Related Information
Breast Feeding Related Information
Children Related Information
Indications for Praziquantel
2.Cerebral Cysticercosis
4.Other Fluke infections
5.Hydatid disease
Interactions for Praziquantel
Typical Dosage for Praziquantel
In Taeniasis: 10mg/kg orally as a single dose. Use a purgative after drug use inTaenia solium infection.
In H. nana: 20mg/kg orally as a single dose.
Cerebral Cysticercosis: 50mg/kg/day orally in divided doses 8hourly for 2 weeks, Up to 1month if required
In Schistosomiasis:
In Schistosoma hematobium: 40mg/kg as a single dose or 20mg/kg twice daily given 4 hour apart.
In Schistosoma japonicum & Schistosoma mansoni: 60mg/kg as a single dose or 20mg/kg thrice daily given 4 hour apart
For other fluke infections: 75mg/kg/day thrice daily in the same day
Schedule of Praziquantel
Storage Requirements for Praziquantel
Store at room temperature. Protect from heat and moisture. Keep out of the reach of children
Effects of Missed Dosage of Praziquantel
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Praziquantel
Give supportive measures and symptomatic treatment.

Home Delivery for Praziquantel in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including praziquantel.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for praziquantel and other medicines and health products. Home delivery services for praziquantel may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take praziquantel only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for praziquantel before they complete the sale. You can get this information while placing the order for praziquantel with the pharmacy.

Praziquantel is a generic medicine name and there are several brands available for it. Some of the brands for praziquantel might be better known than praziquantel itself. If the pharmacy that's willing to deliver medicines to your home doesn't have praziquantel in stock, you can ask for one of the branded alternatives for praziquantel.