- Medicine India
- Generic Medicines
- N
- Pharmacology For Nitazoxanide + Ofloxacin
Nitazoxanide + Ofloxacin Pharmacology
Nitazoxanide + Ofloxacin
About Nitazoxanide + OfloxacinN/AMechanism of Action of Nitazoxanide + OfloxacinN/APharmacokinets of Nitazoxanide + OfloxacinN/AOnset of Action for Nitazoxanide + OfloxacinN/ADuration of Action for Nitazoxanide + OfloxacinN/AHalf Life of Nitazoxanide + OfloxacinN/ASide Effects of Nitazoxanide + OfloxacinN/AContra-indications of Nitazoxanide + OfloxacinN/ASpecial Precautions while taking Nitazoxanide + OfloxacinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Nitazoxanide + OfloxacinN/AInteractions for Nitazoxanide + OfloxacinN/ATypical Dosage for Nitazoxanide + OfloxacinN/ASchedule of Nitazoxanide + OfloxacinN/AStorage Requirements for Nitazoxanide + OfloxacinN/AEffects of Missed Dosage of Nitazoxanide + OfloxacinN/AEffects of Overdose of Nitazoxanide + OfloxacinN/ANitazoxanide
About NitazoxanideA synthetic nitrothiazolyl-salicylamide derivative, Antihelminthics ,in schistosomiasis.Mechanism of Action of NitazoxanideIt excerts its action by blocking anaerobic energy metabolism. The drug interfering with the pyruvate-ferredoxin oxidoreductase enzyme depended electron transfer reaction which is an essential step in anaerobic glucose energy metabolism.
Pharmacokinets of NitazoxanideAbsorption: Well absorbed orally, food increases bioavailability, Distribution: Distributed in a protein bound form, Metabolism: Metabolized in to an active metabolite tizoxanide and then tizoxanide undergoes glucurunide conjugation Excretion: Excreted mainly through bile and faeces and the remaining portion through urine.Onset of Action for Nitazoxanide1 to 4 hoursDuration of Action for NitazoxanideN/AHalf Life of NitazoxanideN/ASide Effects of Nitazoxanide1.Nausea
2.Dizziness
3.Altered appetite
4.Enlarged salivary gland
5.Pruritis
6.Malaise
7.Fever
8.Altered renal function test
9.Elevated liver enzyme level
Contra-indications of Nitazoxanide1.Hypersensitivity to the drugSpecial Precautions while taking Nitazoxanide1.Cardiovascular disorder
2.Diabetes
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Nitazoxanide1.Helminthiasis
2.Giardiasis
3.Amoebiasis
4.Trichomoniasis
5.Fasciolasis
6.Cryptosporidiosis
Interactions for NitazoxanideCaution should be exercised while administering nitazoxanide with drugs which are highly plasma bound.
Typical Dosage for NitazoxanideAs anthelminthic and antiprotozoal:
0.5gm 12hourly along with food for 3days, In Fasciolasis same dosage for a week
Cryptosporidiosis: o.5 gm once a day for 3days
Schedule of NitazoxanideHStorage Requirements for NitazoxanideThe drug should be kept at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children.Effects of Missed Dosage of NitazoxanideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NitazoxanideGive support and symptomatic treatment. Ofloxacin
About OfloxacinA second generation fluoroquinolone(quinolones), Antibiotic.Mechanism of Action of OfloxacinOfloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of OfloxacinAbsorption: Ofloxacin is rapidly and completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Onset of Action for OfloxacinWith in 0.5 hour Duration of Action for Ofloxacin12 - 16 hoursHalf Life of Ofloxacin5 - 8 hoursSide Effects of Ofloxacin1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Constipation
6. Dry mouth
7. Dizziness
8. Headache
9. Rash
10. Pruritis
11. Pseudomembranous colitis
12. Visual disturbances
13. Insomnia
Contra-indications of Ofloxacin1. Hypersensitivity to Ofloxacin and other FluoroquinolonesSpecial Precautions while taking Ofloxacin1. Hepatic impairment
2. Renal impairment
3. Cerebral arteriosclerosis
4. Epilepsy
5. CNS disease
6. Avoid exposure to sunlight
7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Ofloxacin1. Bronchitis
2. Pneumonia
3. Urinary tract infection
4. Bone and joint infections
5. Intra-abdominal infections
6. Gonorrhoea
7. ENT infections
8. Skin and soft tissue infections
9. Typhoid fever
10. Prostatis
11. Otitis
12. Gynaecological infections
13. Conjunctivitis
14. Keratitis
15. Urethritis
16. CervicitisInteractions for OfloxacinOral Anticoagulants: The effects of oral anticoagulants, may be increased.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAID`s: CNS excitation may occur.Typical Dosage for OfloxacinAdults: 200 - 400 mg / day depending on the severity and type of infection
Bronchitis, Pneumonia, Skin and soft tissue infections: 800 mg / day in 2 divided doses for 10 days
Gonorrhoea: 400 mg as a single dose.
Prostatis, Cervicitis & Urethritis: 600 mg / day in 2 divided doses for 1 week.
UTI: 200 - 800 mg / day in single or divided doses
Typhoid fever: 400 - 800 mg / day in 2 divided doses
Schedule of OfloxacinHStorage Requirements for OfloxacinStore at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of OfloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of OfloxacinGive supportive measures and symptomatic treatment. Gastric lavage has to be done. Home Delivery for Nitazoxanide + Ofloxacin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nitazoxanide + ofloxacin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nitazoxanide + ofloxacin and other medicines and health products. Home delivery services for nitazoxanide + ofloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take nitazoxanide + ofloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nitazoxanide + ofloxacin before they complete the sale. You can get this information while placing the order for nitazoxanide + ofloxacin with the pharmacy.
Nitazoxanide + Ofloxacin is a generic medicine name and there are several brands available for it. Some of the brands for nitazoxanide + ofloxacin might be better known than nitazoxanide + ofloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nitazoxanide + ofloxacin in stock, you can ask for one of the branded alternatives for nitazoxanide + ofloxacin.
