The SH groups of Dimercaprol bind those metals ( copper, mercury, iron, lead) which produce their toxicity by interacting with sulfhydryl containing enzymes in the body and forms stable soluble complex which can be easily excreted through urine
Cystinuria: Penicillamine (SH groups) reacts with poorly soluble Cysteine and form water soluble Penicillamine-Cysteine mixed disulphide complex
Rheumatoid arthritis: Penicillamine reduces the concentration of rheumatoid factor IgM and depresses T-cell activity
Primary Biliary cirrhosis, Scleroderma: Penicillamine reduces the concentration of immunoglobulin and immune complex
Metabolism: It is metabolised in the liver to inactive metabolite
Excretion: Drug is excreted in urine and faeces.
12.Loss of taste
18 Ecchymosis (discoloration of the skin)
2.History of Penicillamine related aplastic anaemia or Agranulocytosis
3.Patient allergic to Penicillin
3.Mercury poisoning (alternative to Dimercaprol)
4.Adjuvant to CaNa2EDTA for chronic lead poisoning
6.Primary Biliary cirrhosis
Iron salts (Ferrous sulphate 35%), Antacids (Aluminium hydroxide, Magnesium hydroxide, simethicone mixture; 66%) and Food (52% to 63%) : Absorption of penicillamine is significantly decreased on concommitant administration.
Digoxin: Serum levels of digoxin decreased requiring increase in its dose.
Adult: 1- 1.5 g/day in 4 divided doses
Heavy metal poisoning: 500 mg 1- 3 times daily for 1 - 2 months
Wilson`s disease: 250 -500 mg 4 times daily 30 - 60 minutes before food.
Cystinuria: 500mg 4 times daily
Rheumatoid arthritis: Initial dose: 125 - 250 mg
Primary Biliary cirrhosis: 250 mg / day followed by 250mg increment in every 2 weeks up to 1 g / day in divided doses.
Home Delivery for D-Penicillamine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including d-penicillamine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for d-penicillamine and other medicines and health products. Home delivery services for d-penicillamine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take d-penicillamine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for d-penicillamine before they complete the sale. You can get this information while placing the order for d-penicillamine with the pharmacy.
D-Penicillamine is a generic medicine name and there are several brands available for it. Some of the brands for d-penicillamine might be better known than d-penicillamine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have d-penicillamine in stock, you can ask for one of the branded alternatives for d-penicillamine.