Mesna Pharmacology


About Mesna
Synthetic Thiol derivative, Antidote, Uroprotectant.
Mechanism of Action of Mesna
Mesna rapidly oxidized to major metabolite, mesna disulfide (dimesna). In the kidney dimesna reduced into free thiol compound. This compound reacts with the metabolites of oxazaphosphorins (cyclophosphamide or ifosfamide) to form stable nonurotoxic compounds. During this detoxification there is binding of mesna to the 4-hydroxy-ifosfamide forming a nonurotoxic 4-sulfoethylthioifosfamide.Mesna also bind to the double bonds of acrolein and to other urotoxic metabolites.
Pharmacokinets of Mesna
Absorption-Absorbed well after oral administration
Distribution-This hydrophilic drug does not enter to the tissues.10% bound to the plasma proteins.
Metabolism- It is metabolized into its inactive metabolites i.e.dimesna (mesna disulfide) by oxidation during circulation.
Excretion-Excreted via urine as parent drug (35%) and its metabolite (33%)
Onset of Action for Mesna
Duration of Action for Mesna
Half Life of Mesna
? to 1 ? hrs
Side Effects of Mesna
1. Bad taste in mouth
2. Diarrhea
3. Soft stool
4. Headache
5. Nausea
6. Vomiting
7. Fatigue
8. Blood in urine
9. Skin rash
10. Itching
11. Hypotension
12. Tachycardia
13. Depression
14. Limp pain
Contra-indications of Mesna
Contraindicated in patients with hypersensitivity to mesna and to other thiol containing compounds
Special Precautions while taking Mesna
1. With ketone urea
2. Engaging in activities which require alertness such as driving or using machinery
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Mesna
1. Hemarragic cystitis secondary to cyclophosphamide or ifosamide
2. Toxicity to the urinary passage caused by oxazaphosphorins such as ifosamide
Interactions for Mesna
Typical Dosage for Mesna
Adults-Mesna dose depend upon the amount of ifosfamide and cyclophosphamide that a patient receives. The standard dose depends equal to 20% of the total ifosfamide given at three separate time interval through a vein infused over at least 5 minute, first dose is right before the ifosfamide, often referred to as 0 hr, the 2nd dose is 4 hr after the start of the infusion and the 3rd dose is 8 hrs after the start of infusion.
Mesna can also be administered through orally by mixing with flavoured drink like grape juice, cola, chocolate and milk etc.
Schedule of Mesna
Storage Requirements for Mesna
Stored in a tightly closed container at room temperature, away from light and heat. Keep out of reach of children
Effects of Missed Dosage of Mesna
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Mesna
Give symptomatic and supportive treatment

Home Delivery for Mesna in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mesna.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mesna and other medicines and health products. Home delivery services for mesna may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mesna only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mesna before they complete the sale. You can get this information while placing the order for mesna with the pharmacy.

Mesna is a generic medicine name and there are several brands available for it. Some of the brands for mesna might be better known than mesna itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mesna in stock, you can ask for one of the branded alternatives for mesna.