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- Pharmacology For Amyl Nitrite
Amyl Nitrite Pharmacology
Amyl NitriteAbout Amyl NitriteDirect smooth muscle relaxant( vasodilator), Anti anginal ,antidote in cyanide poisoning.Mechanism of Action of Amyl NitriteIt is a direct smooth muscle relaxant. It is enzymatically denitrated in the smooth muscle cells to release the reactive free radical nitric oxide which activates cytosolic guanylyl cyclase thus increases cyclic GMP levels which causes dephosphorylation of myosin light chain kinase(MLCK) through a cyclic GMP dependent protein kinase. Reduced availability of phosphorylated (active) MLCK interferes with activation of myosin and myosin fails to interact with actin to cause contraction and consequently relaxation occurs. Elevated levels of cyclic GMP also reduce calcium entry which also contributing to relaxation. It dilates veins more than arteries because veins have greater amount of enzyme that generate nitric oxide from nitrates. It works by relaxing blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. Cyanide poisoning: Amylnitrate causes the oxidation of hemoglobin to methemoglobin. Methemoglobin reacts with the cyanide ion to form cyano methemoglobin, which has less affinity for oxygen, thus freeing hemoglobin to react with oxygen.Pharmacokinets of Amyl NitriteAbsorption: It is absorbed after inhalation.Onset of Action for Amyl Nitrite30 secondsDuration of Action for Amyl Nitrite3-20 minutesHalf Life of Amyl NitriteN/ASide Effects of Amyl Nitrite1.Hypotension
Contra-indications of Amyl NitriteHypersensitivity to Amyl NitrateSpecial Precautions while taking Amyl Nitrite1.Use caution when treating poisoning with a combination of cyanide and carbon monoxide
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationMay be usedIndications for Amyl Nitrite1.Cyanide poisoning
Interactions for Amyl NitriteN/ATypical Dosage for Amyl NitriteAdult: 0.3 milliliter (1ampoule). Inhale the vapor through the nose for 30 - 60 seconds and repeat if necessary within 1 - 5 minutes.
Children: same as adult dose
Schedule of Amyl NitriteN/AStorage Requirements for Amyl NitriteKeep out of the reach of children. Keep away from heat and direct light.Effects of Missed Dosage of Amyl NitriteTake the missed dose as soon as notices and if it is the time for next dose continue the regular schedule. Do not double the dose.Effects of Overdose of Amyl NitriteGive supportive measures and symptomatic treatment.
Home Delivery for Amyl Nitrite in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including amyl nitrite.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for amyl nitrite and other medicines and health products. Home delivery services for amyl nitrite may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take amyl nitrite only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for amyl nitrite before they complete the sale. You can get this information while placing the order for amyl nitrite with the pharmacy.
Amyl Nitrite is a generic medicine name and there are several brands available for it. Some of the brands for amyl nitrite might be better known than amyl nitrite itself. If the pharmacy that's willing to deliver medicines to your home doesn't have amyl nitrite in stock, you can ask for one of the branded alternatives for amyl nitrite.