- Medicine India
- Generic Medicines
- Pharmacology For Sotalol
SotalolAbout SotalolBeta (Nonselective) adneregic blocking agent, a potassium channel blocker, Anti-hypertensive,Class III anti-arrhythmic.Mechanism of Action of SotalolSotalol is a non selective beta receptor antagonist. It has negative chronotropic effect on heart. It decreases oxygen consumption; cardiac work and aortic pressure. It increases oxygen supply and exercise tolerance in angina patients. It prolongs duration of monophasic action potentials in atria and ventricles &. Prolongs effective refractory period of AV node, His purkinje system and all cardiac tissues and AV conduction is delayed. It has class 3 antiarrhythmic action of prolonging repolarisation by blocking cardiac K+ channels. It increases ventricular fibrillation threshold in myocardium The drug decreases BP in hypertensive individuals. Initially total peripheral resistance increases due to blockade of beta mediated vasodilatation and decrease in cardiac output; so little change in BP. But when treatment is continued due to adaptation of resistance vessels to decreased cardiac output total peripheral resistance decreases and systolic and diastolic BP falls.Pharmacokinets of SotalolAbsorption: well absorbed orally, Distribution: Widely distributed ,but poorly crosses BBB. Metabolism: Not metabolized in the body. Excretion: Excreted through urine.Onset of Action for Sotalol1-2 hour.Duration of Action for SotalolUpto 24 hours.Half Life of Sotalol7 to18 hoursSide Effects of Sotalol1.Congestive heart failure is precipitated or aggravated
3.Decreases exercise capacity
4.Worsens chronic obstructive lung diseases
10.Prolonged QT interval
11.Altered peripheral circulation
Contra-indications of Sotalol1.Hypersensitivity to the drug
2.Second or third degree heart block
5.Chronic obstructive pulmonary diseases
6.Patient`s with long QT intervals
7.Right ventricular hypertrophy
8.Sick sinus syndrome
12.Upper respiratory infections
Special Precautions while taking Sotalol1. Peripheral arterial diseases
2. Congestive heart failure
3. Renal impairment
4. Hepatic impairment
5. Diabetes mellitus
9. Electrolyte imbalance
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Sotalol1. Hypertension
Interactions for SotalolAntiarrhythmics such as Disopyramide, Quinidine and Procainamide: Prolong refractoriness.
Digoxin: Proarrhythmic events were frequent.
Calcium blocking drugs: Additive effects on atrioventricular conduction, hypotension-hence should be used with caution.
Reserpine, Guanethidine: Hypotension, marked bradycardia which may produce syncope.
Insulin and other antidiabetics: Hyperglycaemia may occur. Symptoms of hypoglycaemia may be masked.
Clonidine: Caution advised when discontinuing clonidine since it may lead to rebound hypertension.
Salbutamol, Isoprenaline & Terbutaline: Efficacy of these drugs decreased.
TCAs, Terfenadine, Astemizole, Phenothiazines: Caution should be observed since these drugs also prolong QT intervals.Typical Dosage for Sotalol80to 160mg/day, increased if required to 320mg/day in arrhythmia & hypertension as single or divided doses. In case of angina dose may be increased up to 360mg/day.
Maximum daily dose: 640mg
.Schedule of SotalolHStorage Requirements for SotalolStore at room temperature in a well closed containerEffects of Missed Dosage of SotalolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SotalolTreatment is supportive and symptomatic. Discontinue the drug and perform haemodialysis. Observes QT interval. Treat Bradycardia with atropine or other anticholinergic drugs & beta adrenergic agonists. Treat heart block with transvenous cardiac pacing. Treat hypotension with vasopressors like epinephrine. Treat cardiac failure with diuretics and cardiac glycosides. Treat bronchospasm with aminophylline. Administer magnesium sulphate, epinephrine, or transvenous cardiac pacing to treat torsades de pointes
Home Delivery for Sotalol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sotalol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sotalol and other medicines and health products. Home delivery services for sotalol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take sotalol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sotalol before they complete the sale. You can get this information while placing the order for sotalol with the pharmacy.
Sotalol is a generic medicine name and there are several brands available for it. Some of the brands for sotalol might be better known than sotalol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sotalol in stock, you can ask for one of the branded alternatives for sotalol.