Sodium Nitroprusside Pharmacology

Sodium Nitroprusside

About Sodium Nitroprusside
Nitrovasodilator, Antihypertensive ,in CHF,MI therapy adjunct.
Mechanism of Action of Sodium Nitroprusside
It is a rapid acting vasodilator. Endothelial cells and RBCs split it in to generate NO which relaxes vascular smooth muscles. It relaxes both resistance and capacitance vessels and thus reduces both preload and after load. It reduces total peripheral resistance, Cardiac output, and decreases the myocardial work.
Pharmacokinets of Sodium Nitroprusside
Absorption: Unstable in alkaline Ph, so should be given intravenously. Metabolism: Metabolized in endothelial cells, RBCs, and liver. Excretion: Excreted through urine.
Onset of Action for Sodium Nitroprusside
Within 30seconds
Duration of Action for Sodium Nitroprusside
Half Life of Sodium Nitroprusside
Side Effects of Sodium Nitroprusside
5.Abdominal pain
8.Lactic acidosis

Contra-indications of Sodium Nitroprusside
1.Hypersensitivity to the drug
2.Compensatory hyper tension

Special Precautions while taking Sodium Nitroprusside
1.Wrap the container with black silver paper to prevent exposure to light
2.Should be administered as I.V. infusion,
3.Lower dosage is required with other anti hypertensive drugs
4.Monitor BP and use infusion pump,
5.Use with caution in Chronic obstructive pulmonary diseases

Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Children Related Information
Indications for Sodium Nitroprusside
1.Hypertensive emergencies
2.Congestive heart failure
3.Acute mitral regurgitation
4.Pump failure during myocardial infarction
5.Produce controlled hypotension during surgery

Interactions for Sodium Nitroprusside
Diuretics, inotropic agents: Useful combination in cardiac failure.
Antihypertensives: Sensitivity enhanced by antihypertensives.
Typical Dosage for Sodium Nitroprusside
Starts with 0.1mcg/kg/minute and gradually increases up to 6mcg/kg/minute based up on the patient`s response
Maximum dose: 8mcg/kg/minute
Children: Starts with I.V. infusion of 0.003mg/kg/minute in dextrose in water solution. Adjust the dosage based on patient`s response up to 0.008mg.
Heart failure: Starts with 10 to 15mcg/kg/minute. Increases based on patient`s response up to 200mcg/kg/minute.
Maximum dose: 4mcg/kg/minute.

Schedule of Sodium Nitroprusside
Storage Requirements for Sodium Nitroprusside
Store in a well wrapped aluminium foil container to protect from light.
Effects of Missed Dosage of Sodium Nitroprusside
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sodium Nitroprusside
Monitor thyocynate concentration & remove drug from the body by haemodialysis. Do supportive & symptomatic treatment

Home Delivery for Sodium Nitroprusside in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sodium nitroprusside.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sodium nitroprusside and other medicines and health products. Home delivery services for sodium nitroprusside may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sodium nitroprusside only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sodium nitroprusside before they complete the sale. You can get this information while placing the order for sodium nitroprusside with the pharmacy.

Sodium Nitroprusside is a generic medicine name and there are several brands available for it. Some of the brands for sodium nitroprusside might be better known than sodium nitroprusside itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sodium nitroprusside in stock, you can ask for one of the branded alternatives for sodium nitroprusside.