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- Pharmacology For Amlodipine + Atenolol
Amlodipine + Atenolol Pharmacology
Amlodipine + AtenololAbout Amlodipine + AtenololN/AMechanism of Action of Amlodipine + AtenololN/APharmacokinets of Amlodipine + AtenololN/AOnset of Action for Amlodipine + AtenololN/ADuration of Action for Amlodipine + AtenololN/AHalf Life of Amlodipine + AtenololN/ASide Effects of Amlodipine + AtenololN/AContra-indications of Amlodipine + AtenololN/ASpecial Precautions while taking Amlodipine + AtenololN/APregnancy Related InformationContraindicated since Amlodipine and Atenolol are contraindicated in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated since Atenolol is contraindicated in lactationChildren Related InformationN/AIndications for Amlodipine + Atenolol1.Hypertension
Interactions for Amlodipine + AtenololN/ATypical Dosage for Amlodipine + AtenololAdult: one tablet once daily
Amlodipine: 5mg + Atenolol: 25mg or
Amlodipine: 5mg + Atenolol: 50mg
Schedule of Amlodipine + AtenololN/AStorage Requirements for Amlodipine + AtenololN/AEffects of Missed Dosage of Amlodipine + AtenololN/AEffects of Overdose of Amlodipine + AtenololN/A
AmlodipineAbout AmlodipineCalcium Channel Blocker, Anti hypertensive,anti angina.Mechanism of Action of AmlodipineAmlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.Pharmacokinets of AmlodipineAbsorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.Onset of Action for AmlodipineSlowDuration of Action for Amlodipine24 hoursHalf Life of AmlodipineN/ASide Effects of Amlodipine1.Palpitation
12.Aggravates myocardial ischaemia
Contra-indications of Amlodipine1.Heart failure
3.Hypersensitivity to the drug
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution.Children Related InformationContraindicatedIndications for Amlodipine1.Hypertension
3.Stable anginaInteractions for AmlodipineACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.Typical Dosage for Amlodipine5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
.Schedule of AmlodipineHStorage Requirements for AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmlodipineMonitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.
AtenololAbout AtenololCardioselective Beta(Beta1 )-adrenergic blocking agent, Antihypertensive,anti anginal.Mechanism of Action of AtenololAtenolol is a cardio selective beta-1 adrenergic antagonist. It has negative chronotropic and negative inotropic effects on heart. It decreases oxygen consumption; cardiac work and aortic pressure. It decreases nor adrenaline and renin releases. It decreases central sympathetic out flow In sympathetic over activity, it prolongs systole by retarding conduction. It increases oxygen supply and exercise tolerance in angina patients. The drug decreases BP in hypertensive individuals; both systolic and diastolic BP is reduced.
Antimigraine action: Atenolol is useful in migraine due to its beta blockade action. Through beta blockade action it inhibits vasodilation and relieves migraine.
Pharmacokinets of AtenololAbsorption: Absorbed orally up to 60%, Distribution: Widely distributed but no CSF penetration Metabolism: A small portion is metabolized in liver. Excretion: Excreted mainly through urine. Remaining portion is excreted through faeces.Onset of Action for Atenolol1hourDuration of Action for AtenololBelow 1dayHalf Life of Atenolol6 - 7 hoursSide Effects of Atenolol1.Heart failure
15.Changes in kidney function tests
16.Changes in liver function tests.
Contra-indications of Atenolol1.Hypersensitivity to the drug
2.Second or third degree heart block
Special Precautions while taking Atenolol1.Congestive heart failure
4.The drug should be gradually withdraw with caution
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Atenolol1.Hypertension
4.Migraine prophylaxisInteractions for AtenololAlcohol, Anaesthetics, Antidepressants, Anxiolytics, Hypnotics, Cimetidine, Diuretics: Enhanced hypotensive effect.
Analgesics: NSAIDs antagonise hypotensive effect.
Antibacterials (Rifampicin): Reduce plasma concentration of atenolol.
Antidiabetics: Enhanced hypoglycemic effect.
Antihypertensives: Enhanced hypotensive effect, with clonidine there is increased severity of rebound hypertension.
Calcium channel Blockers: increased risk of bradycardia and AV block with diltiazem, severe hypotension and heart failure with verapamil, nifedipine
Cardiac glycosides: Increased AV block and bradycardia.
Cholinergics: Effects antagonised by atenolol.
Corticosteroids: Antagonism of hypotensive effect.
Ergotamine: Increased peripheral vasoconstriction
Sympathomimetics: Severe hypertension with adrenaline and noradrenaline.
Lab. Tests: Interferes with Glucose or insulin tolerence tests.Typical Dosage for AtenololHypertension: Starts with 50mg single dose then gradually increases at weekly intervals to 100mg/day once daily based on patient`s response.
Children: 1 to 1.3 mg/kg/day once daily or as two divided doses
Angina: Starts with 50mg single dose orally, and then gradually increases to 100mg/day based on patient`s response at one week intervals
Maximum dose: 200mg/day
Myocardial infarction: 5mg I.V. over 5minuts twice daily at 10minuts intervals. Then after 10minuts starts oral therapy with 50mg dose. Then 50mg at 12th hour. And increases to 100mg/day once daily or in two divided doses up to 9days
Migraine prophylaxis: 50 - 150mg / day in divided doses
Schedule of AtenololHStorage Requirements for AtenololStore at room temperature and protect from heat, moisture, and direct sunlightEffects of Missed Dosage of AtenololTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AtenololTreatment is supportive and symptomatic. After ingestion empty the stomach by induced emesis or gastric lavage. Administer activated charcoal to reduce absorption
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