Amlodipine + Lisinopril Pharmacology

Amlodipine + Lisinopril

About Amlodipine + Lisinopril
Mechanism of Action of Amlodipine + Lisinopril
Pharmacokinets of Amlodipine + Lisinopril
Onset of Action for Amlodipine + Lisinopril
Duration of Action for Amlodipine + Lisinopril
Half Life of Amlodipine + Lisinopril
Side Effects of Amlodipine + Lisinopril
Contra-indications of Amlodipine + Lisinopril
Special Precautions while taking Amlodipine + Lisinopril
Pregnancy Related Information
Contraindicated since Amlodipine and Lisinopril are contraindicated in pregnancy.
Old Age Related Information
Breast Feeding Related Information
Use with caution; since Amlodipine and Lisinopril are used with caution in lactation
Children Related Information
Indications for Amlodipine + Lisinopril
All grades of hypertension.
Interactions for Amlodipine + Lisinopril
Typical Dosage for Amlodipine + Lisinopril
1 tab daily. (amlodipine 5 mg` lisinopril 5 mg)
Schedule of Amlodipine + Lisinopril
Storage Requirements for Amlodipine + Lisinopril
Effects of Missed Dosage of Amlodipine + Lisinopril
Effects of Overdose of Amlodipine + Lisinopril


About Amlodipine
Calcium Channel Blocker, Anti hypertensive,anti angina.
Mechanism of Action of Amlodipine
Amlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.
Pharmacokinets of Amlodipine
Absorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.
Onset of Action for Amlodipine
Duration of Action for Amlodipine
24 hours
Half Life of Amlodipine
Side Effects of Amlodipine
5.Abdominal pain
10.Light headedness
12.Aggravates myocardial ischaemia
Contra-indications of Amlodipine
1.Heart failure
2.Aortic stenosis
3.Hypersensitivity to the drug
4.Unstable angina
5.Hepatic impairment
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine
1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
3.Renal impairment
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution.
Children Related Information
Indications for Amlodipine
2.Prinzmetal`s angina
3.Stable angina
Interactions for Amlodipine
ACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.
Typical Dosage for Amlodipine
5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
Schedule of Amlodipine
Storage Requirements for Amlodipine
Store at room temperature below 30 degree C. Protect from moisture and light.

Effects of Missed Dosage of Amlodipine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Amlodipine
Monitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.


About Lisinopril
Dicarboxylate-containing Angiotensin-Converting Enzyme (ACE) Inhibitor, Antihypertensive.
Mechanism of Action of Lisinopril
It is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. It has no effect on cardiac output and cardiovascular reflexes. There is little dilatation of capacitance vessels; so postural hypotension is not a problem. The drug does not compromise renal, cerebral, and coronary blood flow. BP lowering depending up on sodium status and renin angiotensin activity. So greater fall in BP occurs in Reno vascular accelerated and malignant hypertension. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.
Pharmacokinets of Lisinopril
Absorption: Slowly absorbed orally about 25%.
Distribution: Widely distributed, but poor brain penetration.
Metabolism: Not metabolized in the body.
Excretion: Excreted unchanged in urine.
Onset of Action for Lisinopril
1 hour
Duration of Action for Lisinopril
24 hours
Half Life of Lisinopril
12 hours
Side Effects of Lisinopril
1. Cough
2. Angioedema
3. Hypotension
4. Chest pain
5. Hyperkalemia
6. Rashes
7. Urticaria
8. Swelling of lips mouth nose and larynx
9. Fetopathic in later half of pregnancy
10. Headache
11. Diarrhoea
12. Fatigue
13. Dizziness
14. Nausea
15. Acute renal failure is precipitated in renal artery stenosis

Contra-indications of Lisinopril
1. Hypersensitivity to the drug
2. Renal artery stenosis
3. Aortic stenosis
4. Coarctation of aorta

Special Precautions while taking Lisinopril
1.Renal impairment:
2.Cardiogenic shock
3.Severe heart failure
6.Stops diuretics 2 to 3 days before therapy

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Lisinopril
1. Hypertension
2. Congestive heart failure
Interactions for Lisinopril
Antacids : Decrease efficacy of Lisinopril.
Indomethacin : Reduces hypotensive effect.
Digoxin : Increases plasma digoxin levels.
Potassium preparations & Postassium sparing diuretics : Hyperkalaemia and increased risk of renal failure.
Lithium : Toxicity due to increased serum concentration of Lithium.
Immunosuppressive Drugs : Increased risk of bone marrow depression.
Antidepressants , Diuretics, Beta-Blockers, Phenothiazines : Enhance hypotensive effect.
Morphine : Enhanced analgesic effect and respiratory depression.

Typical Dosage for Lisinopril
Starts with 2.5mg once daily. Increases the dose to 5 to 20mg once daily; depending on patient`s response if required.
Maximum dose: 40mg/day
Schedule of Lisinopril
Storage Requirements for Lisinopril
Store at a temperature range of 15 to 30 degree C. in a well closed container and protect from moisture.
Effects of Missed Dosage of Lisinopril
Effects of Overdose of Lisinopril
Treatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases haemodialysis is considered if required. Treatment includes I.V. infusion of normal saline solution.

Home Delivery for Amlodipine + Lisinopril in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including amlodipine + lisinopril.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for amlodipine + lisinopril and other medicines and health products. Home delivery services for amlodipine + lisinopril may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take amlodipine + lisinopril only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for amlodipine + lisinopril before they complete the sale. You can get this information while placing the order for amlodipine + lisinopril with the pharmacy.

Amlodipine + Lisinopril is a generic medicine name and there are several brands available for it. Some of the brands for amlodipine + lisinopril might be better known than amlodipine + lisinopril itself. If the pharmacy that's willing to deliver medicines to your home doesn't have amlodipine + lisinopril in stock, you can ask for one of the branded alternatives for amlodipine + lisinopril.