- Medicine India
- Generic Medicines
- A
- Pharmacology For Amlodipine + Losartan Potassium
Amlodipine + Losartan Potassium Pharmacology
Amlodipine + Losartan Potassium
About Amlodipine + Losartan PotassiumN/AMechanism of Action of Amlodipine + Losartan PotassiumN/APharmacokinets of Amlodipine + Losartan PotassiumN/AOnset of Action for Amlodipine + Losartan PotassiumN/ADuration of Action for Amlodipine + Losartan PotassiumN/AHalf Life of Amlodipine + Losartan PotassiumN/ASide Effects of Amlodipine + Losartan PotassiumN/AContra-indications of Amlodipine + Losartan PotassiumN/ASpecial Precautions while taking Amlodipine + Losartan PotassiumN/APregnancy Related InformationContraindicated since Amlodipine and Losartan are contraindicated in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated since Losartan is contraindicated in lactation.Children Related InformationN/AIndications for Amlodipine + Losartan PotassiumHypertensionInteractions for Amlodipine + Losartan PotassiumN/ATypical Dosage for Amlodipine + Losartan PotassiumAdult: 1 tablet / day (Amlodipine 5 mg + Losartan 50mg)Schedule of Amlodipine + Losartan PotassiumN/AStorage Requirements for Amlodipine + Losartan PotassiumN/AEffects of Missed Dosage of Amlodipine + Losartan PotassiumN/AEffects of Overdose of Amlodipine + Losartan PotassiumN/AAmlodipine
About AmlodipineCalcium Channel Blocker, Anti hypertensive,anti angina.Mechanism of Action of AmlodipineAmlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.Pharmacokinets of AmlodipineAbsorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.Onset of Action for AmlodipineSlowDuration of Action for Amlodipine24 hoursHalf Life of AmlodipineN/ASide Effects of Amlodipine1.Palpitation
2.Flushing
3.Nausea
4.Vomiting
5.Abdominal pain
6.Edema
7.Headache
8.Dizziness
9.Paresthesia
10.Light headedness
11.Fatigue
12.Aggravates myocardial ischaemia
13.Rashes
Contra-indications of Amlodipine1.Heart failure
2.Aortic stenosis
3.Hypersensitivity to the drug
4.Unstable angina
5.Hepatic impairment
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
3.Renal impairment
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution.Children Related InformationContraindicatedIndications for Amlodipine1.Hypertension
2.Prinzmetal`s angina
3.Stable anginaInteractions for AmlodipineACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.Typical Dosage for Amlodipine5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
.Schedule of AmlodipineHStorage Requirements for AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmlodipineMonitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.Losartan Potassium
About Losartan PotassiumAn angiotensin II receptor antagonist, Antihypertensive.Mechanism of Action of Losartan PotassiumIt is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.Pharmacokinets of Losartan PotassiumAbsorption: Well absorbed orally, but bioavailability is about 33% due to first pass metabolism.
Distribution: Distributed in to the body in a protein bound form, but there is no brain penetration.
Metabolism: Metabolized in the liver in to active carboxylic acid metabolite and other metabolites.
Excretion: Excreted through faeces and urine.
Onset of Action for Losartan Potassium1 hourDuration of Action for Losartan PotassiumN/AHalf Life of Losartan Potassium2 hours
Half life of active metabolite: 6 to 9 hours
Side Effects of Losartan Potassium1. Hypotension
2. Hyperkalemia
3. Headache
4. Breathlessness
5. Chest pain
6. Sore throat
7. Infections
8. Weakness
9. Dizziness
10. Elevated liver enzyme levels
11. Myalgia
12. Fetopathic
13. Precipitate renal failure in renal artery stenosis, and in insufficient renal blood flow
14. Rashes
15. Insomnia
16. Nightmares
Contra-indications of Losartan Potassium1. Hypersensitivity to the drugSpecial Precautions while taking Losartan Potassium1.Hepatic impairment
2.Renal impairment
3.Heart failure
4.Volume depleted individuals
5.Monitor serum potassium levels and avoid use along with potassium sparing diuretics
6. Avoid driving or operating heavy machinery during therapy
7. Avoid alcohol use during therapy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Losartan Potassium1. HypertensionInteractions for Losartan PotassiumDiuretics, other antihypertensives: Potentiate the hypotensive effect of losartan.
Potassium sparing diuretics, potassium suppliments: Risk of hyperkalaemia.
NSAIDs: May blunt hypotensive effect of losartan.
Cytochrome P450 inhibitors like ketoconazole: Increase in AUC of losartan by 18 % but has no effect on its active metabolite.
Phenobarbital: Results in 20% reduction in AUC of losartan and its active metabolite.Typical Dosage for Losartan Potassium25 to 50mg once daily. Gradually increases up to 100mg once daily or as two divided doses.Schedule of Losartan PotassiumHStorage Requirements for Losartan PotassiumStore at room temperature at a range of 15 to 30 degree C. protect from moisture and store in a tightly closed container.Effects of Missed Dosage of Losartan PotassiumTake the missed dose as soon as remember; if it is the time of next dose then skip the missed dose and take the regular dose.Effects of Overdose of Losartan PotassiumTreatment is supportive and symptomatic.Home Delivery for Amlodipine + Losartan Potassium in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including amlodipine + losartan potassium.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for amlodipine + losartan potassium and other medicines and health products. Home delivery services for amlodipine + losartan potassium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take amlodipine + losartan potassium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for amlodipine + losartan potassium before they complete the sale. You can get this information while placing the order for amlodipine + losartan potassium with the pharmacy.
Amlodipine + Losartan Potassium is a generic medicine name and there are several brands available for it. Some of the brands for amlodipine + losartan potassium might be better known than amlodipine + losartan potassium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have amlodipine + losartan potassium in stock, you can ask for one of the branded alternatives for amlodipine + losartan potassium.
