S-Amlodipine + Atenolol Pharmacology

S-Amlodipine + Atenolol

About S-Amlodipine + Atenolol
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Mechanism of Action of S-Amlodipine + Atenolol
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Pharmacokinets of S-Amlodipine + Atenolol
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Onset of Action for S-Amlodipine + Atenolol
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Duration of Action for S-Amlodipine + Atenolol
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Half Life of S-Amlodipine + Atenolol
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Side Effects of S-Amlodipine + Atenolol
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Contra-indications of S-Amlodipine + Atenolol
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Special Precautions while taking S-Amlodipine + Atenolol
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for S-Amlodipine + Atenolol
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Interactions for S-Amlodipine + Atenolol
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Typical Dosage for S-Amlodipine + Atenolol
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Schedule of S-Amlodipine + Atenolol
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Storage Requirements for S-Amlodipine + Atenolol
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Effects of Missed Dosage of S-Amlodipine + Atenolol
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Effects of Overdose of S-Amlodipine + Atenolol
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S-Amlodipine

About S-Amlodipine
Calcium Channel Blocker (dihydropyridine class), Anti hypertensive,anti angina.
Mechanism of Action of S-Amlodipine
S-Amlodipine, which is an enantiomer of Amlodipine; is a dihydropyridine Ca2+ channel blocker. It exerts it`s antihypertensive action through blocking the influx of Ca2+ ions through voltage gated L-type Calcium channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells and causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand and improves oxygen supply to myocardial cells. It directly dilates vascular smooth muscle and reduces hypertension.
Pharmacokinets of S-Amlodipine
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Onset of Action for S-Amlodipine
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Duration of Action for S-Amlodipine
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Half Life of S-Amlodipine
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Side Effects of S-Amlodipine
1.Headache
2.Dizziness
3.Nausea
4.Abdominal pain
5.Fatigue
6.Flushing
7.Pruritus
8.Rash
9.Dyspnea
10.Dyspepsia
11.Muscle spasm

Contra-indications of S-Amlodipine
1.Hyper sensitivity to the drug or other dihydropyridines
2.Hepatic impairment


Special Precautions while taking S-Amlodipine
Hepatic impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for S-Amlodipine
Hypertension
Interactions for S-Amlodipine
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Typical Dosage for S-Amlodipine
2.5mg once daily
Schedule of S-Amlodipine
H
Storage Requirements for S-Amlodipine
Store at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of S-Amlodipine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of S-Amlodipine
Give supportive measures and symptomatic treatment.

Atenolol

About Atenolol
Cardioselective Beta(Beta1 )-adrenergic blocking agent, Antihypertensive,anti anginal.
Mechanism of Action of Atenolol
Atenolol is a cardio selective beta-1 adrenergic antagonist. It has negative chronotropic and negative inotropic effects on heart. It decreases oxygen consumption; cardiac work and aortic pressure. It decreases nor adrenaline and renin releases. It decreases central sympathetic out flow In sympathetic over activity, it prolongs systole by retarding conduction. It increases oxygen supply and exercise tolerance in angina patients. The drug decreases BP in hypertensive individuals; both systolic and diastolic BP is reduced.
Antimigraine action: Atenolol is useful in migraine due to its beta blockade action. Through beta blockade action it inhibits vasodilation and relieves migraine.
Pharmacokinets of Atenolol
Absorption: Absorbed orally up to 60%, Distribution: Widely distributed but no CSF penetration Metabolism: A small portion is metabolized in liver. Excretion: Excreted mainly through urine. Remaining portion is excreted through faeces.
Onset of Action for Atenolol
1hour
Duration of Action for Atenolol
Below 1day
Half Life of Atenolol
6 - 7 hours
Side Effects of Atenolol
1.Heart failure
2.Gastrointestinal problems
3.Nausea
4.Tiredness
5.Sinus bradycardia
6.Depression
7.Rash
8.Dizziess
9.Fatigue
10.Vomiting
11.Diarrhoea
12.Bronchospasm
13.Fever
14.Leg pain
15.Changes in kidney function tests
16.Changes in liver function tests.
Contra-indications of Atenolol
1.Hypersensitivity to the drug
2.Second or third degree heart block
3.Heart failure
4.Cardiogenic shock
5.Sinus bradycardia
Special Precautions while taking Atenolol
1.Congestive heart failure
2.Hepatic impairment
3.Renal impairment
4.The drug should be gradually withdraw with caution
5.Bronchospastic disorders
6.Diabetes mellitus
7.Hyper thyroidism
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Atenolol
1.Hypertension
2. Angina
3.Myocardial infarction
4.Migraine prophylaxis
Interactions for Atenolol
Alcohol, Anaesthetics, Antidepressants, Anxiolytics, Hypnotics, Cimetidine, Diuretics: Enhanced hypotensive effect.
Analgesics: NSAIDs antagonise hypotensive effect.
Antibacterials (Rifampicin): Reduce plasma concentration of atenolol.
Antidiabetics: Enhanced hypoglycemic effect.
Antihypertensives: Enhanced hypotensive effect, with clonidine there is increased severity of rebound hypertension.
Calcium channel Blockers: increased risk of bradycardia and AV block with diltiazem, severe hypotension and heart failure with verapamil, nifedipine
Cardiac glycosides: Increased AV block and bradycardia.
Cholinergics: Effects antagonised by atenolol.
Corticosteroids: Antagonism of hypotensive effect.
Ergotamine: Increased peripheral vasoconstriction
Sympathomimetics: Severe hypertension with adrenaline and noradrenaline.
Lab. Tests: Interferes with Glucose or insulin tolerence tests.
Typical Dosage for Atenolol
Hypertension: Starts with 50mg single dose then gradually increases at weekly intervals to 100mg/day once daily based on patient`s response.
Children: 1 to 1.3 mg/kg/day once daily or as two divided doses
Angina: Starts with 50mg single dose orally, and then gradually increases to 100mg/day based on patient`s response at one week intervals
Maximum dose: 200mg/day
Myocardial infarction: 5mg I.V. over 5minuts twice daily at 10minuts intervals. Then after 10minuts starts oral therapy with 50mg dose. Then 50mg at 12th hour. And increases to 100mg/day once daily or in two divided doses up to 9days
Migraine prophylaxis: 50 - 150mg / day in divided doses
Schedule of Atenolol
H
Storage Requirements for Atenolol
Store at room temperature and protect from heat, moisture, and direct sunlight
Effects of Missed Dosage of Atenolol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Atenolol
Treatment is supportive and symptomatic. After ingestion empty the stomach by induced emesis or gastric lavage. Administer activated charcoal to reduce absorption

Home Delivery for S-Amlodipine + Atenolol in Your City

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Please be aware that you should take s-amlodipine + atenolol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for s-amlodipine + atenolol before they complete the sale. You can get this information while placing the order for s-amlodipine + atenolol with the pharmacy.

S-Amlodipine + Atenolol is a generic medicine name and there are several brands available for it. Some of the brands for s-amlodipine + atenolol might be better known than s-amlodipine + atenolol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have s-amlodipine + atenolol in stock, you can ask for one of the branded alternatives for s-amlodipine + atenolol.