S-Amlodipine + Ramipril Pharmacology

S-Amlodipine + Ramipril

About S-Amlodipine + Ramipril
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Mechanism of Action of S-Amlodipine + Ramipril
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Pharmacokinets of S-Amlodipine + Ramipril
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Onset of Action for S-Amlodipine + Ramipril
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Duration of Action for S-Amlodipine + Ramipril
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Half Life of S-Amlodipine + Ramipril
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Side Effects of S-Amlodipine + Ramipril
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Contra-indications of S-Amlodipine + Ramipril
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Special Precautions while taking S-Amlodipine + Ramipril
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for S-Amlodipine + Ramipril
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Interactions for S-Amlodipine + Ramipril
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Typical Dosage for S-Amlodipine + Ramipril
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Schedule of S-Amlodipine + Ramipril
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Storage Requirements for S-Amlodipine + Ramipril
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Effects of Missed Dosage of S-Amlodipine + Ramipril
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Effects of Overdose of S-Amlodipine + Ramipril
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S-Amlodipine

About S-Amlodipine
Calcium Channel Blocker (dihydropyridine class), Anti hypertensive,anti angina.
Mechanism of Action of S-Amlodipine
S-Amlodipine, which is an enantiomer of Amlodipine; is a dihydropyridine Ca2+ channel blocker. It exerts it`s antihypertensive action through blocking the influx of Ca2+ ions through voltage gated L-type Calcium channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells and causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand and improves oxygen supply to myocardial cells. It directly dilates vascular smooth muscle and reduces hypertension.
Pharmacokinets of S-Amlodipine
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Onset of Action for S-Amlodipine
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Duration of Action for S-Amlodipine
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Half Life of S-Amlodipine
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Side Effects of S-Amlodipine
1.Headache
2.Dizziness
3.Nausea
4.Abdominal pain
5.Fatigue
6.Flushing
7.Pruritus
8.Rash
9.Dyspnea
10.Dyspepsia
11.Muscle spasm

Contra-indications of S-Amlodipine
1.Hyper sensitivity to the drug or other dihydropyridines
2.Hepatic impairment


Special Precautions while taking S-Amlodipine
Hepatic impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for S-Amlodipine
Hypertension
Interactions for S-Amlodipine
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Typical Dosage for S-Amlodipine
2.5mg once daily
Schedule of S-Amlodipine
H
Storage Requirements for S-Amlodipine
Store at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of S-Amlodipine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of S-Amlodipine
Give supportive measures and symptomatic treatment.

Ramipril

About Ramipril
Angiotensin - converting enzyme inhibitor, Antihypertensive.
Mechanism of Action of Ramipril
It is a prodrug and converted in to active Ramiprilat; which is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.
Pharmacokinets of Ramipril
Absorption: Absorbed orally up to 60%, Distribution: Widely distributed in the tissues, Metabolism: Metabolized in the body in to active metabolite, Ramiprilat. Excretion: Excreted mainly through urine and also excreted through faeces.
Onset of Action for Ramipril
1 to 2 hours
Duration of Action for Ramipril
24 hours
Half Life of Ramipril
8 to 48 hours
Side Effects of Ramipril
1.Cough
2.Angioedema
3.Hypotension
4.Chest pain
5.Hyperkalemia
6.Rashes
7.Urticaria
8.Swelling of lips, mouth, nose, and larynx
9.Fetopathic in later half of pregnancy
10.Headache
11.Diarrhoea
12.Fatigue
13.Dizziness
14.Nausea
15.Neutropenia
16.Thrombocytopenia
17.Acute renal failure is precipitated in renal artery stenosis


Contra-indications of Ramipril
1.Hypersensitivity to the drug
2.Renal artery stenosis
3.Aortic stenosis
4.Coarctation of aorta

Special Precautions while taking Ramipril
1.Renal impairment
2.Hepatic impairment
3.Use cautiously in patient at high risk of cardiogenic shock, severe heart failure etc
4.Anaesthesia and surgery

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Ramipril
1.Hypertension
2.Heart failure

Interactions for Ramipril
Antacids: May decrease bioavailability of ramipril.
Phenothiazines: Pharmacologic effects enhanced by phenothiazines.
Allupurinol: Higher risk of hypersensitivity reactions.
Digoxin: Increases plasma digoxin levels.
Potassium preparations & Potassium sparing diuretics: Hyperkalaemia and increased risk of renal failure.
Lithium: Toxicity due to increased serum concentration of lithium.
Typical Dosage for Ramipril
Starts with 1.25mg once daily. Increases the dose to 2.5 to 5mg once daily; depending on patient`s response.
Maximum dose: 10mg once daily.
In CHF patients starts the dosage with 1.5mg once daily dosage and gradually increases at 2 to3 weeks` intervals to usual dosage.

Schedule of Ramipril
H
Storage Requirements for Ramipril
Store at a temperature range of 15 to 30 degree C. in a well closed container and protect from moisture.






Effects of Missed Dosage of Ramipril
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ramipril
Treatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases haemodialysis is considered if required. Treatment includes I.V. infusion of normal saline solution.

Home Delivery for S-Amlodipine + Ramipril in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for s-amlodipine + ramipril and other medicines and health products. Home delivery services for s-amlodipine + ramipril may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take s-amlodipine + ramipril only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for s-amlodipine + ramipril before they complete the sale. You can get this information while placing the order for s-amlodipine + ramipril with the pharmacy.

S-Amlodipine + Ramipril is a generic medicine name and there are several brands available for it. Some of the brands for s-amlodipine + ramipril might be better known than s-amlodipine + ramipril itself. If the pharmacy that's willing to deliver medicines to your home doesn't have s-amlodipine + ramipril in stock, you can ask for one of the branded alternatives for s-amlodipine + ramipril.