Lacidipine Pharmacology


About Lacidipine
Selective calcium channel blocker, Dihydropyridine derivative, Antihypertensive.
Mechanism of Action of Lacidipine
Lacidipine is a vasoselective long acting dihydropyridine Ca channel blocker. It exerts antihypertensive action through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, and blood pressure. It exerts some anti atherosclerotic properties by modulating the secretion of matrix degrading metalloproteinase-9 by human macrophages and thus weakens the atherosclerotic plaque. It also has antioxidant properties and it prevents platelet aggregation.
Pharmacokinets of Lacidipine
Absorption: Rapidly but poorly absorbed orally, bioavailability is reduced due to first pass metabolism.
Distribution: Widely distributed in a protein bound form.
Metabolism: Metabolized in liver.
Excretion: Excreted mainly through bile and faeces and small amount is excreted through urine.
Onset of Action for Lacidipine
Duration of Action for Lacidipine
Half Life of Lacidipine
13 to 19 hours
Side Effects of Lacidipine
1. Flushing
2. Palpitation
3. Hypotension
4. Nausea
5. Edema
6. Headache
7. Dizziness
8. Bradycardia
9. Fatigue
10. Paraesthesia
11. Gastrointestinal disturbances
12. Rash
13. Muscle cramps
14. Disturbance of mood
15. Hyperplasia of gum
Contra-indications of Lacidipine
1. Acute myocardial infarction
2. Aortic stenosis
3. Hypotension
4. Cardiogenic shock
5. Hypersensitivity to the drug
6. Unstable angina

Special Precautions while taking Lacidipine
1. Congestive heart failure
2. Cardiovascular insufficiency
3. Hypotension
4. Left ventricular outflow obstruction
5. Conduction abnormalities
6. Hepatic impairment
7. Slowly withdraw the drug with caution.
8. Use cautiously along with other antihypertensive drugs.
9. Stops the drug if ischaemic chest pain or Cardiogenic shock occurs after starting therapy.
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Lacidipine
1. Hypertension
Interactions for Lacidipine
Avoid grape fruit juice as it may affect metabolism. Other interactions as with calcium channel blockers.
Typical Dosage for Lacidipine
Starts with 2mg once daily. Increased to 4mg/day if required after 3 to 4 weeks
Maximum dose: 6mg

Schedule of Lacidipine
Storage Requirements for Lacidipine
Store in a cool, dry place below 30 degree C. Protect from direct heat and light. Keep out of reach of children.
Effects of Missed Dosage of Lacidipine
Take the missed dose as soon as remember and If it is the time for next dose then skip the missed dose and take the regular dose.
Effects of Overdose of Lacidipine
Treatment is supportive and symptomatic.Monitor & support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.

Home Delivery for Lacidipine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lacidipine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lacidipine and other medicines and health products. Home delivery services for lacidipine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lacidipine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lacidipine before they complete the sale. You can get this information while placing the order for lacidipine with the pharmacy.

Lacidipine is a generic medicine name and there are several brands available for it. Some of the brands for lacidipine might be better known than lacidipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lacidipine in stock, you can ask for one of the branded alternatives for lacidipine.