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- Pharmacology For S-Amlodipine + Atorvastatin
S-Amlodipine + Atorvastatin Pharmacology
S-Amlodipine + Atorvastatin
About S-Amlodipine + AtorvastatinN/AMechanism of Action of S-Amlodipine + AtorvastatinN/APharmacokinets of S-Amlodipine + AtorvastatinN/AOnset of Action for S-Amlodipine + AtorvastatinN/ADuration of Action for S-Amlodipine + AtorvastatinN/AHalf Life of S-Amlodipine + AtorvastatinN/ASide Effects of S-Amlodipine + AtorvastatinN/AContra-indications of S-Amlodipine + AtorvastatinN/ASpecial Precautions while taking S-Amlodipine + AtorvastatinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for S-Amlodipine + AtorvastatinN/AInteractions for S-Amlodipine + AtorvastatinN/ATypical Dosage for S-Amlodipine + AtorvastatinN/ASchedule of S-Amlodipine + AtorvastatinN/AStorage Requirements for S-Amlodipine + AtorvastatinN/AEffects of Missed Dosage of S-Amlodipine + AtorvastatinN/AEffects of Overdose of S-Amlodipine + AtorvastatinN/AS-Amlodipine
About S-AmlodipineCalcium Channel Blocker (dihydropyridine class), Anti hypertensive,anti angina.Mechanism of Action of S-AmlodipineS-Amlodipine, which is an enantiomer of Amlodipine; is a dihydropyridine Ca2+ channel blocker. It exerts it`s antihypertensive action through blocking the influx of Ca2+ ions through voltage gated L-type Calcium channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells and causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand and improves oxygen supply to myocardial cells. It directly dilates vascular smooth muscle and reduces hypertension.Pharmacokinets of S-AmlodipineN/AOnset of Action for S-AmlodipineN/ADuration of Action for S-AmlodipineN/AHalf Life of S-AmlodipineN/ASide Effects of S-Amlodipine1.Headache
2.Dizziness
3.Nausea
4.Abdominal pain
5.Fatigue
6.Flushing
7.Pruritus
8.Rash
9.Dyspnea
10.Dyspepsia
11.Muscle spasm
Contra-indications of S-Amlodipine1.Hyper sensitivity to the drug or other dihydropyridines
2.Hepatic impairment
Special Precautions while taking S-AmlodipineHepatic impairmentPregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for S-AmlodipineHypertensionInteractions for S-AmlodipineN/ATypical Dosage for S-Amlodipine2.5mg once dailySchedule of S-AmlodipineHStorage Requirements for S-AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.Effects of Missed Dosage of S-AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of S-AmlodipineGive supportive measures and symptomatic treatment.Atorvastatin
About AtorvastatinHMG-CoA Reductase Inhibitor, statins, Antilipemic agent.Mechanism of Action of AtorvastatinIt is a more potent statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels. It also exerts antioxidant property.Pharmacokinets of AtorvastatinAbsorption: Readily absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in liver in to active metabolite, Excretion: Excreted mainly through bile.Onset of Action for AtorvastatinN/ADuration of Action for AtorvastatinN/AHalf Life of Atorvastatin18 to 24 hoursSide Effects of Atorvastatin1.Headache
2.Dizziness
3.Insomnia
4.Alopecia
5.Anorexia
6.Abdominal discomfort
7.Heart burn
8.Abdominal pain
9.Nausea
10.Dyspepsia
11.Flatulence
12.Constipation
13.Abnormal liver function tests
14.Rash
15.Pruritus
16.Fatigue
17.Myositis
18.Chest pain
19.Impotence
20.Myopathy
21.Upper respiratory tract infections
Contra-indications of Atorvastatin1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
Special Precautions while taking Atorvastatin
1.Monitor hepatic function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
3.Alcoholics
4.In severe adverse effects and fever
Pregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Below 9years: ContraindicatedIndications for Atorvastatin1.Hypercholesterolemia
2.Combined hyperlipidaemia
Interactions for AtorvastatinN/ATypical Dosage for AtorvastatinOral:
Starts with 10mg once daily; Increased if required based on patients response.
Maximum dose: 80mg
Schedule of AtorvastatinHStorage Requirements for AtorvastatinStore at room temperature at a range of 15 to 25 degree C.Effects of Missed Dosage of AtorvastatinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AtorvastatinProvide supportive care and symptomatic treatment.Home Delivery for S-Amlodipine + Atorvastatin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including s-amlodipine + atorvastatin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for s-amlodipine + atorvastatin and other medicines and health products. Home delivery services for s-amlodipine + atorvastatin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take s-amlodipine + atorvastatin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for s-amlodipine + atorvastatin before they complete the sale. You can get this information while placing the order for s-amlodipine + atorvastatin with the pharmacy.
S-Amlodipine + Atorvastatin is a generic medicine name and there are several brands available for it. Some of the brands for s-amlodipine + atorvastatin might be better known than s-amlodipine + atorvastatin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have s-amlodipine + atorvastatin in stock, you can ask for one of the branded alternatives for s-amlodipine + atorvastatin.
