Nimodipine Pharmacology


About Nimodipine
A dihydropyridine calcium channel blocker, Treatment of neurologic defects associated with subarachnoid hemorrhage.
Mechanism of Action of Nimodipine
Nimodipine is a Ca channel blocker. It exerts its actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the vascular smooth muscle and resulting in relaxation of vascular smooth muscles. Being highly lipophilic it has greater action on the cerebral vessels.
Pharmacokinets of Nimodipine
Absorption: It is rapidly absorbed after oral administration.
Distribution: Nimodipine is widely distributed in the body in protein bound form.
Metabolism: It undergoes metabolism in the liver.
Excretion: It is excreted mainly through urine
Onset of Action for Nimodipine
With in 30 minutes
Duration of Action for Nimodipine
4 - 6 hours
Half Life of Nimodipine
8-9 hours
Side Effects of Nimodipine
1. Hypotension
2. Tachycardia
3. Headache
4. Dizziness
5. Nausea
6. Abdominal discomfort
7. Flushing Fatigue
8. Muscle pain
Contra-indications of Nimodipine
1. Hypersensitivity to Nimodipine
Special Precautions while taking Nimodipine
1. Renal impairment
2. Hepatic impairment
3. Cerebral edema
4. Increased intracranial pressure
5. Congestive heart failure
6. Severe ventricular dysfunction
7. Decreased gastric motility
8. Slowly withdraw the drug with caution
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES : Contraindicated
Indications for Nimodipine
1. Prevention of cerebral vasospasm and resultant ischemia following subarachnoid haemorrhage.
Interactions for Nimodipine
Other calcium channel blockers: Increase its effect.
Phenytoin & caffeine: Increased toxicity of these drugs due to decreased hepatic metabolism.
Typical Dosage for Nimodipine
Adult: 60 mg every 4 hours for 3 weeks beginning within 4 days of onset of haemorrhage
Schedule of Nimodipine
Storage Requirements for Nimodipine
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light.
Effects of Missed Dosage of Nimodipine
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose and take that dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Nimodipine
Give supportive measures and symptomatic treatment.

Home Delivery for Nimodipine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nimodipine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nimodipine and other medicines and health products. Home delivery services for nimodipine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nimodipine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nimodipine before they complete the sale. You can get this information while placing the order for nimodipine with the pharmacy.

Nimodipine is a generic medicine name and there are several brands available for it. Some of the brands for nimodipine might be better known than nimodipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nimodipine in stock, you can ask for one of the branded alternatives for nimodipine.