Lisinopril Pharmacology

Lisinopril

About Lisinopril

Dicarboxylate-containing Angiotensin-Converting Enzyme (ACE) Inhibitor, Antihypertensive.

Mechanism of Action of Lisinopril

It is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. It has no effect on cardiac output and cardiovascular reflexes. There is little dilatation of capacitance vessels; so postural hypotension is not a problem. The drug does not compromise renal, cerebral, and coronary blood flow. BP lowering depending up on sodium status and renin angiotensin activity. So greater fall in BP occurs in Reno vascular accelerated and malignant hypertension. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.

Pharmacokinets of Lisinopril

Absorption: Slowly absorbed orally about 25%.
Distribution: Widely distributed, but poor brain penetration.
Metabolism: Not metabolized in the body.
Excretion: Excreted unchanged in urine.

Onset of Action for Lisinopril

1 hour

Duration of Action for Lisinopril

24 hours

Half Life of Lisinopril

12 hours

Side Effects of Lisinopril

1. Cough
2. Angioedema
3. Hypotension
4. Chest pain
5. Hyperkalemia
6. Rashes
7. Urticaria
8. Swelling of lips mouth nose and larynx
9. Fetopathic in later half of pregnancy
10. Headache
11. Diarrhoea
12. Fatigue
13. Dizziness
14. Nausea
15. Acute renal failure is precipitated in renal artery stenosis

Contra-indications of Lisinopril

1. Hypersensitivity to the drug
2. Renal artery stenosis
3. Aortic stenosis
4. Coarctation of aorta

Special Precautions while taking Lisinopril

1.Renal impairment:
2.Cardiogenic shock
3.Severe heart failure
4.Anaesthesia
5.Surgery
6.Stops diuretics 2 to 3 days before therapy

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Contraindicated

Indications for Lisinopril

1. Hypertension
2. Congestive heart failure

Interactions for Lisinopril

Antacids : Decrease efficacy of Lisinopril.
Indomethacin : Reduces hypotensive effect.
Digoxin : Increases plasma digoxin levels.
Potassium preparations & Postassium sparing diuretics : Hyperkalaemia and increased risk of renal failure.
Lithium : Toxicity due to increased serum concentration of Lithium.
Immunosuppressive Drugs : Increased risk of bone marrow depression.
Antidepressants , Diuretics, Beta-Blockers, Phenothiazines : Enhance hypotensive effect.
Morphine : Enhanced analgesic effect and respiratory depression.

Typical Dosage for Lisinopril

Starts with 2.5mg once daily. Increases the dose to 5 to 20mg once daily; depending on patient`s response if required.
Maximum dose: 40mg/day

Schedule of Lisinopril

Storage Requirements for Lisinopril

Store at a temperature range of 15 to 30 degree C. in a well closed container and protect from moisture.

Effects of Missed Dosage of Lisinopril

N/A

Effects of Overdose of Lisinopril

Treatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases haemodialysis is considered if required. Treatment includes I.V. infusion of normal saline solution.

Home Delivery for Lisinopril in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lisinopril.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lisinopril and other medicines and health products. Home delivery services for lisinopril may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lisinopril only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lisinopril before they complete the sale. You can get this information while placing the order for lisinopril with the pharmacy.

Lisinopril is a generic medicine name and there are several brands available for it. Some of the brands for lisinopril might be better known than lisinopril itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lisinopril in stock, you can ask for one of the branded alternatives for lisinopril.