Trandolapril Pharmacology

Trandolapril

About Trandolapril

Angiotensin converting enzyme inhibitor, Antihypertensive.

Mechanism of Action of Trandolapril

It is a prodrug and converted in to active Trandolaprilat in the body which is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.

Pharmacokinets of Trandolapril

Absorption: Absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in the body in to active metabolite, Trandolaprilat and other metabolites
Excretion: Excreted mainly through faeces and also excreted through urine

Onset of Action for Trandolapril

N/A

Duration of Action for Trandolapril

24 hour

Half Life of Trandolapril

6 to 10 hours

Side Effects of Trandolapril

1.Cough
2.Angioedema
3.Hypotension
4.Chest pain
5.Arrhythmia
6.Hyperkalemia
7.Upper respiratory tract infections
8.Rashes
9.Urticaria
10.Impotence
11.Swelling of lips, mouth, nose, and larynx
12.Fetopathic in later half of pregnancy
13.Headache
14.Diarrhoea
15.Fatigue
16.Dizziness
17.Nausea
18.Neutropenia
19.Leucopenia
20.Elevated liver enzymes
21.Acute renal failure is precipitated in renal artery stenosis

Contra-indications of Trandolapril

1.Hypersensitivity to the drug
2.Renal artery stenosis
3.Aortic stenosis
4.Coarctation of aorta

Special Precautions while taking Trandolapril

1.Renal impairment:
2.Hepatic impairment
3.Use cautiously in patient at high risk of cardiogenic shock, severe heart failure etc
4.Anaesthesia and surgery

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated

Indications for Trandolapril

1.Hypertension
2.Heart failure
3.Left ventricular dysfunction after myocardial infarction

Interactions for Trandolapril

N/A

Typical Dosage for Trandolapril

Starts with 5mg once daily. Gradually increases the dose at weekly intervals up to 2mg once daily; depending on patient`s response.
Maximum dose: 4mg once daily.

Schedule of Trandolapril

Storage Requirements for Trandolapril

Store at a temperature range of 15 to 30 degree C. in a well closed container and protect from moisture.

Effects of Missed Dosage of Trandolapril

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Trandolapril

Treatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases haemodialysis is considered if required. Monitor serum potassium level and renal fuction.Treatment includes I.V. infusion of normal saline solution.

Home Delivery for Trandolapril in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including trandolapril.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for trandolapril and other medicines and health products. Home delivery services for trandolapril may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take trandolapril only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for trandolapril before they complete the sale. You can get this information while placing the order for trandolapril with the pharmacy.

Trandolapril is a generic medicine name and there are several brands available for it. Some of the brands for trandolapril might be better known than trandolapril itself. If the pharmacy that's willing to deliver medicines to your home doesn't have trandolapril in stock, you can ask for one of the branded alternatives for trandolapril.