Perindopril Pharmacology


About Perindopril
A long-acting Dicarboxylate-containing ACE inhibitor, Antihypertensive.
Mechanism of Action of Perindopril
It is a prodrug and converted in to active Perindoprilat; which is a long acting angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. The drug restores the reduced elastic properties of arteries and heart in hypertensive individuals. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.

Pharmacokinets of Perindopril
Absorption: Well absorbed orally, Distribution: It is distributed in to the body, Metabolism: Metabolized in the body in to active metabolite, Perindoprilat; and other inactive metabolites Excretion: Excreted mainly through urine.
Onset of Action for Perindopril
Duration of Action for Perindopril
24 hour
Half Life of Perindopril
Side Effects of Perindopril
3.Chest pain
7.Swelling of lips, mouth, nose, and larynx
8.Fetopathic in later half of pregnancy
12.Sleep disturbances
18.Decreased haemoglobin count
20.Elevated liver enzymes
21.Acute renal failure is precipitated in renal artery stenosis

Contra-indications of Perindopril
1.Hypersensitivity to the drug
2.Renal artery stenosis
3.Aortic stenosis
4.Coarctation of aorta

Special Precautions while taking Perindopril
1.Renal impairment
2.Hepatic impairment
3.Ischaemic heart disease
4.Severe heart failure
5.Collagen vascular diseases
7.Cerebrovascular diseases
8.Lower dosage is needed for elderly

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Perindopril
2.Congestive heart failure
Interactions for Perindopril
Nitrates, Diuretics, Beta-blockers, Anti-depressants, Alcohol, Calcium channel blockers: Enhanced hypotensive effect.
Potassium sparing diuretics: Hyperkalaemia.
Sex hormones: Oestrogens and combined oral contraceptives antagonise hypotensive effect.
Typical Dosage for Perindopril
Starts with 4mg; orally once daily. Increases the dose to 8mg once daily or in two divided doses; after one month of therapy depending on patient`s response.
Maximum dose: 16mg/day
In CHF patients starts the dosage with 2mg once daily dosage and gradually increases at 1 to2 weeks` intervals to 4mg or further increase in dose depends up on patient`s response.

Schedule of Perindopril
Storage Requirements for Perindopril
Store at a temperature range of 15 to 30 degree C. in a well closed container and protect from light and moisture.

Effects of Missed Dosage of Perindopril
Effects of Overdose of Perindopril
Treatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases haemodialysis is considered if required. Treatment includes I.V. infusion of normal saline solution to treat hypotension. Treat dehydration and maintain electrolyte balance.

Home Delivery for Perindopril in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including perindopril.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for perindopril and other medicines and health products. Home delivery services for perindopril may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take perindopril only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for perindopril before they complete the sale. You can get this information while placing the order for perindopril with the pharmacy.

Perindopril is a generic medicine name and there are several brands available for it. Some of the brands for perindopril might be better known than perindopril itself. If the pharmacy that's willing to deliver medicines to your home doesn't have perindopril in stock, you can ask for one of the branded alternatives for perindopril.